| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Zileuton perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Zileuton_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.139039 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.129155 |
| HMGA2 | high mobility group AT-hook 2 | 0.0549265 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0504486 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0493399 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0482007 |
| EGR1 | early growth response 1 | 0.0451702 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0435639 |
| EHBP1 | EH domain binding protein 1 | 0.038673 |
| VCL | vinculin | 0.0361403 |
| TMSB10 | thymosin beta 10 | 0.0354703 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.034927 |
| BCHE | butyrylcholinesterase | 0.031986 |
| POTEF | POTE ankyrin domain family, member F | 0.0310598 |
| TGM2 | transglutaminase 2 | 0.0284014 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0262155 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.025992 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0257561 |
| NAV3 | neuron navigator 3 | 0.0247092 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0232222 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0226202 |
| PDGFC | platelet derived growth factor C | 0.0225873 |
| DST | dystonin | 0.0221461 |
| ADIPOR2 | adiponectin receptor 2 | 0.0216493 |
| ACTG1 | actin gamma 1 | 0.0206909 |
| NHSL1 | NHS-like 1 | 0.0206744 |
| GCG | glucagon | 0.0206064 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0205253 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0204776 |
| EDARADD | EDAR-associated death domain | 0.0198181 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0193901 |
| MYPN | myopalladin | 0.0192698 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0184266 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0179598 |
| FSTL5 | follistatin-like 5 | 0.0177309 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.017651 |
| COMMD10 | COMM domain containing 10 | 0.0172837 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0169996 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0168988 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0168642 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0161426 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0159861 |
| RASAL2 | RAS protein activator like 2 | 0.0157294 |
| CEP112 | centrosomal protein 112kDa | 0.0155674 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0155519 |
| COL5A2 | collagen, type V, alpha 2 | 0.0152348 |
| CMIP | c-Maf inducing protein | 0.015231 |
| TPM4 | tropomyosin 4 | 0.0148754 |
| MTAP | methylthioadenosine phosphorylase | 0.014761 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0146727 |
| TENM3 | teneurin transmembrane protein 3 | 0.014062 |
| SETX | senataxin | 0.0134272 |
| KRT8 | keratin 8, type II | 0.0131003 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.013034 |
| RPL4 | ribosomal protein L4 | 0.0129708 |
| MAP1B | microtubule-associated protein 1B | 0.01297 |
| RCOR1 | REST corepressor 1 | 0.0126118 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0124757 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | 0.012439 |
| RSU1 | Ras suppressor protein 1 | 0.0124356 |
| KIF18B | kinesin family member 18B | 0.0121896 |
| CUX1 | cut-like homeobox 1 | 0.0121577 |
| ENO1 | enolase 1, (alpha) | 0.0121197 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0120594 |
| INTS6 | integrator complex subunit 6 | 0.0119604 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0118996 |
| NEBL | nebulette | 0.0118158 |
| PHF14 | PHD finger protein 14 | 0.011459 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0114007 |
| TUBA1B | tubulin, alpha 1b | 0.0113786 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.0112615 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0111971 |
| FAM110C | family with sequence similarity 110, member C | 0.0111785 |
| KSR2 | kinase suppressor of ras 2 | 0.0111414 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0110182 |
| ZNF804A | zinc finger protein 804A | 0.0109955 |
| TMEM108 | transmembrane protein 108 | 0.0108785 |
| YAP1 | Yes-associated protein 1 | 0.0106811 |
| CLIC1 | chloride intracellular channel 1 | 0.0106559 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | 0.0105624 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0103793 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0103568 |
| FADS2 | fatty acid desaturase 2 | 0.0102719 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.010203 |
| HDAC9 | histone deacetylase 9 | 0.0100721 |
| TTC27 | tetratricopeptide repeat domain 27 | 0.00997722 |
| ATP9A | ATPase, class II, type 9A | 0.00997069 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.00994425 |
| AIG1 | androgen-induced 1 | 0.00992808 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.00988274 |
| GATAD2A | GATA zinc finger domain containing 2A | 0.00979334 |
| PCNX4 | pecanex 4 | 0.00973663 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.00973027 |
| MSR1 | macrophage scavenger receptor 1 | 0.00972007 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.00967172 |
| OSMR | oncostatin M receptor | 0.00946387 |
| NCAM2 | neural cell adhesion molecule 2 | 0.00944848 |
| KRT18 | keratin 18, type I | 0.00931314 |
| VCAN | versican | 0.00926604 |
| LATS2 | large tumor suppressor kinase 2 | 0.00901749 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | -0.178884 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.139869 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.120665 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.106595 |
| RPS2 | ribosomal protein S2 | -0.0897586 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0841347 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0830471 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.064984 |
| VIM | vimentin | -0.0625867 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0620036 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0600571 |
| PCBP2 | poly(rC) binding protein 2 | -0.0599814 |
| KIF5B | kinesin family member 5B | -0.0599244 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0598324 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0588749 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0560839 |
| MGAT4C | MGAT4 family, member C | -0.0537871 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0524334 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0522579 |
| XPO1 | exportin 1 | -0.0508735 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.05083 |
| ZNF292 | zinc finger protein 292 | -0.0507291 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0499622 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0498416 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0494096 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0484925 |
| RPS12 | ribosomal protein S12 | -0.0481528 |
| RPS6 | ribosomal protein S6 | -0.0471014 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0461085 |
| RBM39 | RNA binding motif protein 39 | -0.0447923 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0444226 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0441336 |
| PTMA | prothymosin, alpha | -0.0439793 |
| PRRC2C | proline-rich coiled-coil 2C | -0.042487 |
| EXOC6B | exocyst complex component 6B | -0.0423434 |
| TXNRD1 | thioredoxin reductase 1 | -0.0421152 |
| RPS8 | ribosomal protein S8 | -0.0420923 |
| CPOX | coproporphyrinogen oxidase | -0.0413817 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0413485 |
| USP34 | ubiquitin specific peptidase 34 | -0.040054 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0394884 |
| SQSTM1 | sequestosome 1 | -0.039435 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0391498 |
| SPAG9 | sperm associated antigen 9 | -0.0391201 |
| RPS3 | ribosomal protein S3 | -0.0389718 |
| CLTC | clathrin, heavy chain (Hc) | -0.0382104 |
| FTL | ferritin, light polypeptide | -0.0375169 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0370106 |
| FBXO11 | F-box protein 11 | -0.0368593 |
| OGA | O-GlcNAcase | -0.0366659 |
| CCNL1 | cyclin L1 | -0.0365072 |
| EDN1 | endothelin 1 | -0.0364198 |
| RPL26 | ribosomal protein L26 | -0.0363726 |
| ATP11A | ATPase, class VI, type 11A | -0.0357883 |
| MED13L | mediator complex subunit 13-like | -0.0348719 |
| ANXA1 | annexin A1 | -0.034711 |
| KLHL24 | kelch-like family member 24 | -0.0346957 |
| GOLGA4 | golgin A4 | -0.0344967 |
| SETD5 | SET domain containing 5 | -0.0337955 |
| RPL19 | ribosomal protein L19 | -0.0337627 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0337254 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0336716 |
| NEK7 | NIMA-related kinase 7 | -0.0331686 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0330823 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0330163 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.03297 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0329192 |
| MATR3 | matrin 3 | -0.0327908 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0326288 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0325028 |
| RPL7 | ribosomal protein L7 | -0.0324926 |
| RRM2 | ribonucleotide reductase M2 | -0.0323116 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0320898 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0320429 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0315253 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0314638 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0314488 |
| CEP192 | centrosomal protein 192kDa | -0.0311085 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0309715 |
| PRKCI | protein kinase C, iota | -0.0306988 |
| RPL38 | ribosomal protein L38 | -0.0305915 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0305352 |
| SEPTIN7 | septin 7 | -0.0303956 |
| CANX | calnexin | -0.0303886 |
| PCM1 | pericentriolar material 1 | -0.0303792 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0303758 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.030228 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0301849 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0299842 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0295767 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0295153 |
| TPR | translocated promoter region, nuclear basket protein | -0.0293024 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0291919 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0291825 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0290775 |
| RPL37A | ribosomal protein L37a | -0.0289812 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0288091 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0284248 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0283607 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0281806 |
