Zileuton_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Zileuton perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Zileuton_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.110948
PTBP3 polypyrimidine tract binding protein 3 0.0816102
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0699565
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.069786
ZMYND8 zinc finger, MYND-type containing 8 0.0684536
NCKAP5 NCK-associated protein 5 0.0676668
NRIP1 nuclear receptor interacting protein 1 0.0649289
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0606525
IFNGR1 interferon gamma receptor 1 0.0586992
SPATA13 spermatogenesis associated 13 0.0533469
RNF43 ring finger protein 43 0.0501451
BTBD9 BTB (POZ) domain containing 9 0.047069
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0451888
RNF149 ring finger protein 149 0.0432269
TXNIP thioredoxin interacting protein 0.042876
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0423397
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0410792
N4BP2L2 NEDD4 binding protein 2-like 2 0.0410551
TJP2 tight junction protein 2 0.0400123
IL20RA interleukin 20 receptor, alpha 0.0392695
TMEM62 transmembrane protein 62 0.0388325
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0386982
ABHD2 abhydrolase domain containing 2 0.0372328
SPRED1 sprouty-related, EVH1 domain containing 1 0.037071
ZMYM2 zinc finger, MYM-type 2 0.0369907
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0361819
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0359952
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0348131
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0346032
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0340914
MACC1 metastasis associated in colon cancer 1 0.0338792
FAT1 FAT atypical cadherin 1 0.0336377
SORBS1 sorbin and SH3 domain containing 1 0.0325977
PTEN phosphatase and tensin homolog 0.0324659
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0323549
UBAC2 UBA domain containing 2 0.0319834
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0315911
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0314031
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0313697
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.031186
CDC42SE2 CDC42 small effector 2 0.0310715
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0310686
ZDHHC20 zinc finger, DHHC-type containing 20 0.0303182
SERINC5 serine incorporator 5 0.0300951
TSC22D1 TSC22 domain family, member 1 0.0298499
STK24 serine/threonine kinase 24 0.0294836
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0293928
OARD1 O-acyl-ADP-ribose deacylase 1 0.0292513
RUNX1 runt-related transcription factor 1 0.029016
RBM26 RNA binding motif protein 26 0.0287138
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0286766
ALPK1 alpha-kinase 1 0.0285212
ATP10B ATPase, class V, type 10B 0.028393
ARHGAP32 Rho GTPase activating protein 32 0.0279691
EPSTI1 epithelial stromal interaction 1 (breast) 0.0276832
USP3 ubiquitin specific peptidase 3 0.026853
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0266845
PATJ PATJ crumbs cell polarity complex component 0.0263665
ARHGAP5 Rho GTPase activating protein 5 0.0262056
ZBTB20 zinc finger and BTB domain containing 20 0.0261639
YAP1 Yes-associated protein 1 0.026159
RHOBTB3 Rho-related BTB domain containing 3 0.0252796
CAB39 calcium binding protein 39 0.0250845
PRSS3 protease, serine, 3 0.0250837
ADAM10 ADAM metallopeptidase domain 10 0.0250837
MEIS2 Meis homeobox 2 0.0250421
PRELID2 PRELI domain containing 2 0.0249142
USP54 ubiquitin specific peptidase 54 0.0247539
DENND4C DENN/MADD domain containing 4C 0.0242208
PDZD8 PDZ domain containing 8 0.024215
AOPEP aminopeptidase O (putative) 0.0238971
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0237638
ETV6 ets variant 6 0.023642
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0232433
FNIP1 folliculin interacting protein 1 0.0229137
ETNK1 ethanolamine kinase 1 0.0228072
NPEPPS aminopeptidase puromycin sensitive 0.0227745
ARHGAP26 Rho GTPase activating protein 26 0.0225595
SLK STE20-like kinase 0.0222754
GSK3B glycogen synthase kinase 3 beta 0.0220354
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0218033
SAMD4A sterile alpha motif domain containing 4A 0.0217648
WDFY3 WD repeat and FYVE domain containing 3 0.021744
LMTK2 lemur tyrosine kinase 2 0.0215836
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0214107
PLS1 plastin 1 0.0213417
SH3RF1 SH3 domain containing ring finger 1 0.0211275
FNDC3A fibronectin type III domain containing 3A 0.0210664
MICU2 mitochondrial calcium uptake 2 0.020834
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0208262
ABHD17C abhydrolase domain containing 17C 0.0207842
PCED1B PC-esterase domain containing 1B 0.0207765
CTNND1 catenin (cadherin-associated protein), delta 1 0.0207471
HBS1L HBS1-like translational GTPase 0.0206729
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0204818
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0203681
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0202939
PHF3 PHD finger protein 3 0.0201996
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0201009
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0200516

decreased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 -0.156778
TPT1 tumor protein, translationally-controlled 1 -0.154519
EZR ezrin -0.137195
LMO7 LIM domain 7 -0.13567
ANXA2 annexin A2 -0.127968
EGR1 early growth response 1 -0.123554
SQSTM1 sequestosome 1 -0.114827
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.112121
B2M beta-2-microglobulin -0.102501
RNF213 ring finger protein 213 -0.0958021
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.088005
RAB7A RAB7A, member RAS oncogene family -0.0786957
PTMA prothymosin, alpha -0.0741745
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0737072
IRF1 interferon regulatory factor 1 -0.0736005
RIGI RNA sensor RIG-I -0.0685949
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0679095
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0642622
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0636524
GMDS GDP-mannose 4,6-dehydratase -0.0605198
PLSCR2 phospholipid scramblase 2 -0.0585112
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0578927
LCN2 lipocalin 2 -0.0578494
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0577144
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0573003
SEC31A SEC31 homolog A (S. cerevisiae) -0.0564384
GCLC glutamate-cysteine ligase, catalytic subunit -0.0548262
HM13 histocompatibility (minor) 13 -0.0537371
RRBP1 ribosome binding protein 1 -0.0537156
PERP PERP, TP53 apoptosis effector -0.0514079
MORF4L2 mortality factor 4 like 2 -0.0505814
NPSR1 neuropeptide S receptor 1 -0.0495469
JUN jun proto-oncogene -0.0493962
SP100 SP100 nuclear antigen -0.0464435
EFNB2 ephrin-B2 -0.0463012
AREG amphiregulin -0.0459392
HLA-B major histocompatibility complex, class I, B -0.0455199
LOC102724023 ES1 protein homolog, mitochondrial -0.045356
MCL1 myeloid cell leukemia 1 -0.0440103
GOLGB1 golgin B1 -0.0434664
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0434144
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.042983
TJP1 tight junction protein 1 -0.0427804
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0427672
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0425796
PKM pyruvate kinase, muscle -0.0425478
UGDH UDP-glucose 6-dehydrogenase -0.042308
IFI6 interferon, alpha-inducible protein 6 -0.0409082
ACTG1 actin gamma 1 -0.040465
RPS6 ribosomal protein S6 -0.0400796
RPL23 ribosomal protein L23 -0.0400438
TMSB10 thymosin beta 10 -0.0385659
NABP1 nucleic acid binding protein 1 -0.0381701
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0378518
BLZF1 basic leucine zipper nuclear factor 1 -0.0374254
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0367094
FTL ferritin, light polypeptide -0.0355118
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0353389
PHACTR4 phosphatase and actin regulator 4 -0.0350774
ITPKC inositol-trisphosphate 3-kinase C -0.0346863
RPL35A ribosomal protein L35a -0.0344873
FUS FUS RNA binding protein -0.0344736
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.034464
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0342485
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0336621
S100A10 S100 calcium binding protein A10 -0.0329024
SPAG9 sperm associated antigen 9 -0.03287
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0327674
TM4SF19 transmembrane 4 L six family member 19 -0.0326515
LMNA lamin A/C -0.0323493
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0323298
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0320948
STS steroid sulfatase (microsomal), isozyme S -0.0320651
UBAP2 ubiquitin associated protein 2 -0.0319744
PDIA3 protein disulfide isomerase family A, member 3 -0.0319566
MT2A metallothionein 2A -0.0317304
DDIT3 DNA-damage-inducible transcript 3 -0.0314389
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0312419
MX2 MX dynamin-like GTPase 2 -0.0307849
IFI27 interferon, alpha-inducible protein 27 -0.0307315
CALR calreticulin -0.0305073
PLSCR1 phospholipid scramblase 1 -0.0303547
VCL vinculin -0.0301621
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.029644
CALU calumenin -0.0296207
TOP1 topoisomerase (DNA) I -0.0295093
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0293246
LYZ lysozyme -0.0293155
MX1 MX dynamin-like GTPase 1 -0.0291852
DUSP10 dual specificity phosphatase 10 -0.0291762
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.029132
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0290601
MYO1E myosin IE -0.0288655
RPLP1 ribosomal protein, large, P1 -0.0287196
LAMA4 laminin, alpha 4 -0.0286471
ANXA1 annexin A1 -0.028372
ACTN4 actinin, alpha 4 -0.0281446
TSHZ2 teashirt zinc finger homeobox 2 -0.0280934
SEC24A SEC24 family member A -0.0278572
SPDYA speedy/RINGO cell cycle regulator family member A -0.0278503