Zileuton_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Zileuton perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Zileuton_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0538717
PSD3 pleckstrin and Sec7 domain containing 3 0.0407472
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.034176
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0319225
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0311817
EXT1 exostosin glycosyltransferase 1 0.0302708
FNDC3B fibronectin type III domain containing 3B 0.0231235
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0230208
WWTR1 WW domain containing transcription regulator 1 0.0225035
PRELID2 PRELI domain containing 2 0.0220209
GLIS3 GLIS family zinc finger 3 0.0192375
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.018981
HMGA2 high mobility group AT-hook 2 0.0187162
DOCK5 dedicator of cytokinesis 5 0.0185458
ERRFI1 ERBB receptor feedback inhibitor 1 0.0180636
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0175076
DPYD dihydropyrimidine dehydrogenase 0.0167707
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0166616
PDLIM5 PDZ and LIM domain 5 0.0166083
DST dystonin 0.0162535
VMP1 vacuole membrane protein 1 0.0156901
VCL vinculin 0.0154604
NAV1 neuron navigator 1 0.0154012
VEGFA vascular endothelial growth factor A 0.0145886
PDE10A phosphodiesterase 10A 0.0142742
VEGFC vascular endothelial growth factor C 0.0135152
JARID2 jumonji, AT rich interactive domain 2 0.0133381
HIPK2 homeodomain interacting protein kinase 2 0.0132863
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0130422
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0129719
ANO6 anoctamin 6 0.012637
FNIP1 folliculin interacting protein 1 0.012544
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0123273
ASPH aspartate beta-hydroxylase 0.0123244
DPYSL3 dihydropyrimidinase-like 3 0.0118757
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0113991
EFNA5 ephrin-A5 0.0110872
HAS2 hyaluronan synthase 2 0.0110866
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0108257
NAV2 neuron navigator 2 0.0108074
ADAM19 ADAM metallopeptidase domain 19 0.010608
ZBTB20 zinc finger and BTB domain containing 20 0.0105313
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0105282
ELL2 elongation factor, RNA polymerase II, 2 0.0105224
ANTXR2 anthrax toxin receptor 2 0.010485
ADAM12 ADAM metallopeptidase domain 12 0.0104436
EGFR epidermal growth factor receptor 0.0100806
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0100776
MYH9 myosin, heavy chain 9, non-muscle 0.00997212
LHFPL2 lipoma HMGIC fusion partner-like 2 0.00980761
RAI14 retinoic acid induced 14 0.00979142
ZEB2 zinc finger E-box binding homeobox 2 0.009657
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0096204
SBF2 SET binding factor 2 0.00954309
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00947163
CNTN5 contactin 5 0.00943017
SMYD3 SET and MYND domain containing 3 0.00927076
NRIP1 nuclear receptor interacting protein 1 0.00924681
KDM7A lysine (K)-specific demethylase 7A 0.00922485
ATXN1 ataxin 1 0.00920068
MSN moesin 0.00919434
MACF1 microtubule-actin crosslinking factor 1 0.00918246
PICALM phosphatidylinositol binding clathrin assembly protein 0.0091177
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00911346
ANKRD36 ankyrin repeat domain 36 0.00910141
LTBP1 latent transforming growth factor beta binding protein 1 0.00900693
KIRREL3 kin of IRRE like 3 (Drosophila) 0.00896959
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00896482
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0089041
STK38L serine/threonine kinase 38 like 0.00884958
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00869129
HDAC9 histone deacetylase 9 0.00865669
MBNL1 muscleblind-like splicing regulator 1 0.00862745
PDE4D phosphodiesterase 4D, cAMP-specific 0.0086123
FER fer (fps/fes related) tyrosine kinase 0.00858401
YEATS2 YEATS domain containing 2 0.00851941
FAT1 FAT atypical cadherin 1 0.00837527
SDC2 syndecan 2 0.00829194
CPQ carboxypeptidase Q 0.0082697
MTSS1 metastasis suppressor 1 0.00826054
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.00815535
USP47 ubiquitin specific peptidase 47 0.00783143
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0077851
OSMR oncostatin M receptor 0.00762937
RUNX1 runt-related transcription factor 1 0.00762864
JAK2 Janus kinase 2 0.00753764
NPC1 Niemann-Pick disease, type C1 0.0075301
ATP13A3 ATPase type 13A3 0.00751868
COL5A1 collagen, type V, alpha 1 0.00715221
MAP1B microtubule-associated protein 1B 0.00712511
CD109 CD109 molecule 0.00707703
NRP1 neuropilin 1 0.00706557
NOTCH2 notch 2 0.00701158
SLC22A23 solute carrier family 22, member 23 0.00693546
RIGI RNA sensor RIG-I 0.00691741
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0068966
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.00687665
ABLIM3 actin binding LIM protein family, member 3 0.00679464
FAM20C family with sequence similarity 20, member C 0.00679381
ARHGAP29 Rho GTPase activating protein 29 0.00672554

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.24301
VIM vimentin -0.199678
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163569
MT2A metallothionein 2A -0.126408
COL1A1 collagen, type I, alpha 1 -0.117339
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.115591
TMSB10 thymosin beta 10 -0.0977012
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0917724
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0840349
IER3 immediate early response 3 -0.0761331
PTMA prothymosin, alpha -0.0752207
RPS8 ribosomal protein S8 -0.0744928
FTL ferritin, light polypeptide -0.0701882
IGFBP3 insulin-like growth factor binding protein 3 -0.0699609
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0658245
RPS6 ribosomal protein S6 -0.0637168
COL1A2 collagen, type I, alpha 2 -0.0616246
RPL35A ribosomal protein L35a -0.0586204
FN1 fibronectin 1 -0.0581968
CALR calreticulin -0.0486171
NDRG1 N-myc downstream regulated 1 -0.0469001
ACTG1 actin gamma 1 -0.0464538
TGFBI transforming growth factor, beta-induced, 68kDa -0.0432812
NAMPT nicotinamide phosphoribosyltransferase -0.0428254
TPM4 tropomyosin 4 -0.0422346
ENO1 enolase 1, (alpha) -0.0415567
EIF1 eukaryotic translation initiation factor 1 -0.0394874
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0388799
RPL23 ribosomal protein L23 -0.0388081
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0387753
RPL8 ribosomal protein L8 -0.038033
RPL11 ribosomal protein L11 -0.0380092
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0376135
S100A9 S100 calcium binding protein A9 -0.0369821
LDHA lactate dehydrogenase A -0.0357198
RPS19 ribosomal protein S19 -0.0355549
RPLP1 ribosomal protein, large, P1 -0.0355489
CADM1 cell adhesion molecule 1 -0.0347533
RPS3 ribosomal protein S3 -0.0344334
B2M beta-2-microglobulin -0.0343115
RPL19 ribosomal protein L19 -0.0342081
TPT1 tumor protein, translationally-controlled 1 -0.0337923
UBC ubiquitin C -0.0335548
RACK1 receptor for activated C kinase 1 -0.032422
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0320313
RPL28 ribosomal protein L28 -0.0319094
CANX calnexin -0.0316633
HLA-B major histocompatibility complex, class I, B -0.0314966
CAVIN1 caveolae associated protein 1 -0.0313867
RPL12 ribosomal protein L12 -0.0303133
RPL30 ribosomal protein L30 -0.0300883
RPL5 ribosomal protein L5 -0.0299189
RPS20 ribosomal protein S20 -0.0297678
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0297209
RPL7 ribosomal protein L7 -0.0293518
RPL26 ribosomal protein L26 -0.0291617
TMSB4X thymosin beta 4, X-linked -0.0288732
MT1X metallothionein 1X -0.0280628
FTH1 ferritin, heavy polypeptide 1 -0.0280016
PKM pyruvate kinase, muscle -0.0275213
RPL37A ribosomal protein L37a -0.0274198
RPLP2 ribosomal protein, large, P2 -0.0270648
RPLP0 ribosomal protein, large, P0 -0.0265324
YBX1 Y box binding protein 1 -0.0263387
GNAS GNAS complex locus -0.0262759
RPL36 ribosomal protein L36 -0.0262083
RPL34 ribosomal protein L34 -0.0257101
ANXA2 annexin A2 -0.025635
RPS12 ribosomal protein S12 -0.0255233
NAP1L1 nucleosome assembly protein 1-like 1 -0.025472
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0254058
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.025365
EEF2 eukaryotic translation elongation factor 2 -0.0253629
DSTN destrin (actin depolymerizing factor) -0.0251923
S100A6 S100 calcium binding protein A6 -0.0251826
S100A10 S100 calcium binding protein A10 -0.0250019
ALCAM activated leukocyte cell adhesion molecule -0.0248898
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0248712
MTDH metadherin -0.0247258
COL3A1 collagen, type III, alpha 1 -0.0245175
WSB1 WD repeat and SOCS box containing 1 -0.0244713
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.024465
RPS5 ribosomal protein S5 -0.0243339
RPL37 ribosomal protein L37 -0.0241169
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0239979
SEPTIN7 septin 7 -0.0238894
LMAN1 lectin, mannose-binding, 1 -0.0237845
RRBP1 ribosome binding protein 1 -0.0237093
RPS14 ribosomal protein S14 -0.023637
RPL32 ribosomal protein L32 -0.0236358
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0235435
RPS13 ribosomal protein S13 -0.0234651
RPS25 ribosomal protein S25 -0.0232189
RPS24 ribosomal protein S24 -0.0228361
LOC112694756 uncharaterized LOC112694756 -0.0225817
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0225637
SOD2 superoxide dismutase 2, mitochondrial -0.0225476
TM4SF1 transmembrane 4 L six family member 1 -0.0225383
RPS11 ribosomal protein S11 -0.022333
POSTN periostin, osteoblast specific factor -0.0222422