| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Zileuton perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Zileuton_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.0696073 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.058832 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0585726 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0439821 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0399483 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0366893 |
| FN1 | fibronectin 1 | 0.0357011 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0356529 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0347926 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0345931 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.033339 |
| ASPH | aspartate beta-hydroxylase | 0.0316128 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0284614 |
| ATXN1 | ataxin 1 | 0.0275964 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0273952 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0266812 |
| INTS6 | integrator complex subunit 6 | 0.0266319 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0252487 |
| FOXO1 | forkhead box O1 | 0.0252301 |
| FAT1 | FAT atypical cadherin 1 | 0.0249914 |
| DST | dystonin | 0.0232451 |
| SMAD3 | SMAD family member 3 | 0.0232034 |
| RPL4 | ribosomal protein L4 | 0.0223663 |
| MYO1E | myosin IE | 0.0216508 |
| JAG1 | jagged 1 | 0.0206172 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0204971 |
| VMP1 | vacuole membrane protein 1 | 0.0200303 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0191122 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0188102 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0186266 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0182652 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0181575 |
| DTNA | dystrobrevin, alpha | 0.0180755 |
| USP53 | ubiquitin specific peptidase 53 | 0.0179788 |
| MYO5B | myosin VB | 0.0178041 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0175042 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0173753 |
| FILIP1L | filamin A interacting protein 1-like | 0.0173692 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0173326 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0167608 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0164912 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0164025 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0163787 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0163708 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0162938 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0162195 |
| ITGAV | integrin, alpha V | 0.0161224 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0160933 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0160339 |
| MYO6 | myosin VI | 0.016033 |
| MRTFA | myocardin related transcription factor A | 0.0157081 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | 0.0153685 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0153352 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0153016 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0150163 |
| NUP98 | nucleoporin 98kDa | 0.0149377 |
| USP47 | ubiquitin specific peptidase 47 | 0.0148725 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0147625 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.014547 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0145184 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0144839 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0144809 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0143697 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0142274 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0142112 |
| RAB10 | RAB10, member RAS oncogene family | 0.0141902 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0141382 |
| RUNX1 | runt-related transcription factor 1 | 0.0140601 |
| PCGF5 | polycomb group ring finger 5 | 0.0140102 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0138619 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0137391 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0136654 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0136284 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.013585 |
| FAM107B | family with sequence similarity 107, member B | 0.0135157 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0134291 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.013235 |
| PALLD | palladin, cytoskeletal associated protein | 0.0129511 |
| JAK1 | Janus kinase 1 | 0.0128917 |
| BCL2L1 | BCL2-like 1 | 0.0128774 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0128766 |
| FOXP1 | forkhead box P1 | 0.0128015 |
| ABI1 | abl-interactor 1 | 0.0127529 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 | 0.0126445 |
| HNMT | histamine N-methyltransferase | 0.0126153 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0126009 |
| TNS1 | tensin 1 | 0.0125977 |
| MEMO1 | mediator of cell motility 1 | 0.0125263 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0124839 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0124679 |
| KIF1B | kinesin family member 1B | 0.0123106 |
| NUMB | numb homolog (Drosophila) | 0.0122959 |
| AHR | aryl hydrocarbon receptor | 0.012143 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.012108 |
| LUZP1 | leucine zipper protein 1 | 0.0121014 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0120843 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0119468 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0119043 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0118676 |
| JMJD1C | jumonji domain containing 1C | 0.011825 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.50333 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.254589 |
| MT2A | metallothionein 2A | -0.180169 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.161613 |
| IGF2 | insulin-like growth factor 2 | -0.122301 |
| RPS6 | ribosomal protein S6 | -0.109876 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.103926 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0940617 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0883086 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0852083 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0838542 |
| FTL | ferritin, light polypeptide | -0.0788465 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0771157 |
| ENO1 | enolase 1, (alpha) | -0.0713079 |
| GPC3 | glypican 3 | -0.0705098 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0698128 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0667958 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0628111 |
| RPLP0 | ribosomal protein, large, P0 | -0.0617459 |
| RPL11 | ribosomal protein L11 | -0.0609013 |
| C3 | complement component 3 | -0.0535803 |
| RPLP1 | ribosomal protein, large, P1 | -0.0502133 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0496777 |
| RPS8 | ribosomal protein S8 | -0.0482862 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0449824 |
| APOA2 | apolipoprotein A-II | -0.0430788 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0407899 |
| RPS19 | ribosomal protein S19 | -0.0392806 |
| TMSB10 | thymosin beta 10 | -0.0379824 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0379119 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0376844 |
| RPS12 | ribosomal protein S12 | -0.0373449 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0364938 |
| RACK1 | receptor for activated C kinase 1 | -0.0364166 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0363249 |
| RPL12 | ribosomal protein L12 | -0.0362187 |
| CPE | carboxypeptidase E | -0.0361344 |
| PCBP2 | poly(rC) binding protein 2 | -0.0358448 |
| PEG3 | paternally expressed 3 | -0.0350377 |
| AHSG | alpha-2-HS-glycoprotein | -0.034569 |
| APOA1 | apolipoprotein A-I | -0.0345046 |
| HMGA1 | high mobility group AT-hook 1 | -0.0344441 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0339325 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0338582 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0338225 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0335373 |
| RPL32 | ribosomal protein L32 | -0.0326873 |
| RPL26 | ribosomal protein L26 | -0.0319552 |
| KLF6 | Kruppel-like factor 6 | -0.0318611 |
| APOE | apolipoprotein E | -0.0315602 |
| S100A9 | S100 calcium binding protein A9 | -0.0312583 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0309785 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0308219 |
| RPL27A | ribosomal protein L27a | -0.0305591 |
| RPS3 | ribosomal protein S3 | -0.0304731 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0302257 |
| MT1X | metallothionein 1X | -0.0296983 |
| SDC4 | syndecan 4 | -0.0296825 |
| RPL34 | ribosomal protein L34 | -0.0296078 |
| RPL8 | ribosomal protein L8 | -0.0295588 |
| PERP | PERP, TP53 apoptosis effector | -0.0291225 |
| RPS14 | ribosomal protein S14 | -0.0290216 |
| RPLP2 | ribosomal protein, large, P2 | -0.0290139 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0288964 |
| RPS5 | ribosomal protein S5 | -0.0286588 |
| RPL37A | ribosomal protein L37a | -0.0283884 |
| RBM25 | RNA binding motif protein 25 | -0.0283806 |
| GOLGA4 | golgin A4 | -0.0281499 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0281229 |
| PTMA | prothymosin, alpha | -0.0276378 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0273961 |
| RPS24 | ribosomal protein S24 | -0.0273953 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.026933 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0268736 |
| RPL23 | ribosomal protein L23 | -0.026787 |
| LYZ | lysozyme | -0.0267777 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0264934 |
| UBC | ubiquitin C | -0.026258 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0256169 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.025565 |
| RRBP1 | ribosome binding protein 1 | -0.0254723 |
| GNAS | GNAS complex locus | -0.0254461 |
| LDHA | lactate dehydrogenase A | -0.0247747 |
| RPL35A | ribosomal protein L35a | -0.0245901 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0244029 |
| JUN | jun proto-oncogene | -0.0242819 |
| TF | transferrin | -0.023775 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0237104 |
| FAM162A | family with sequence similarity 162, member A | -0.0235838 |
| RPS23 | ribosomal protein S23 | -0.0233549 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0232739 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0230273 |
| IER3 | immediate early response 3 | -0.0228987 |
| RPL19 | ribosomal protein L19 | -0.0228221 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0228084 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0227746 |
| WDR45B | WD repeat domain 45B | -0.0227456 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0227176 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0226627 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0226084 |
