Zileuton_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Zileuton perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Zileuton_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA6 integrin, alpha 6 0.155503
MUC6 mucin 6, oligomeric mucus/gel-forming 0.152945
FAT1 FAT atypical cadherin 1 0.122575
KRT8 keratin 8, type II 0.107023
DSPP dentin sialophosphoprotein 0.0892059
CEMIP cell migration inducing protein, hyaluronan binding 0.085875
FLNB filamin B, beta 0.0845683
PTPRR protein tyrosine phosphatase, receptor type, R 0.0816729
NDRG1 N-myc downstream regulated 1 0.073919
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0731365
NPSR1 neuropeptide S receptor 1 0.0726996
LMO7 LIM domain 7 0.0709733
TXNIP thioredoxin interacting protein 0.0706887
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0703301
PPARG peroxisome proliferator-activated receptor gamma 0.0673821
ESYT2 extended synaptotagmin-like protein 2 0.0670181
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0664567
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0655146
NALF1 NALCN channel auxiliary factor 1 0.0640488
EEF2 eukaryotic translation elongation factor 2 0.0634743
CALB1 calbindin 1, 28kDa 0.0628132
PTEN phosphatase and tensin homolog 0.060465
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0579107
ABHD2 abhydrolase domain containing 2 0.0563935
ASPH aspartate beta-hydroxylase 0.0542011
PRELID2 PRELI domain containing 2 0.0499498
POTEF POTE ankyrin domain family, member F 0.0491931
ITPRID2 ITPR interacting domain containing 2 0.0488172
LDHA lactate dehydrogenase A 0.0474513
UBA6 ubiquitin-like modifier activating enzyme 6 0.0461851
VEGFA vascular endothelial growth factor A 0.0454709
GCC2 GRIP and coiled-coil domain containing 2 0.0442757
PRSS3 protease, serine, 3 0.0440842
FAM13A family with sequence similarity 13, member A 0.0439676
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0418797
EZR ezrin 0.041453
GREB1L growth regulation by estrogen in breast cancer-like 0.0413022
KLF3 Kruppel-like factor 3 (basic) 0.0411469
ANXA2 annexin A2 0.0410603
ARHGAP26 Rho GTPase activating protein 26 0.0410511
ITGB4 integrin, beta 4 0.040544
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0400684
PELI1 pellino E3 ubiquitin protein ligase 1 0.0400617
RNF217 ring finger protein 217 0.0396608
SLK STE20-like kinase 0.0394615
EHF ets homologous factor 0.0390328
RPL3 ribosomal protein L3 0.038875
RREB1 ras responsive element binding protein 1 0.037687
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0373132
FTH1 ferritin, heavy polypeptide 1 0.0368449
CCNY cyclin Y 0.0359359
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.035706
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.034998
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0346244
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0345818
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0339799
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0339682
TNS4 tensin 4 0.0335369
ARHGAP32 Rho GTPase activating protein 32 0.0335307
PSD3 pleckstrin and Sec7 domain containing 3 0.033505
SBF2 SET binding factor 2 0.0333281
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0328958
CD46 CD46 molecule, complement regulatory protein 0.0321631
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0320889
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0319563
MAML2 mastermind-like 2 (Drosophila) 0.0318132
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0315771
ENO1 enolase 1, (alpha) 0.0312088
VMP1 vacuole membrane protein 1 0.0309283
AKAP13 A kinase (PRKA) anchor protein 13 0.0307774
MACF1 microtubule-actin crosslinking factor 1 0.0305488
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0303669
ZFP36L1 ZFP36 ring finger protein-like 1 0.0303478
BIRC6 baculoviral IAP repeat containing 6 0.0302409
TBC1D5 TBC1 domain family, member 5 0.0300461
CENPF centromere protein F, 350/400kDa 0.0299727
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0298647
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0293583
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0290395
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0289196
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0285909
ARHGAP12 Rho GTPase activating protein 12 0.0285705
RNF145 ring finger protein 145 0.0285198
TPM3 tropomyosin 3 0.0282996
MED13 mediator complex subunit 13 0.0282419
CLDN7 claudin 7 0.0281881
ADAM19 ADAM metallopeptidase domain 19 0.0281638
MUC17 mucin 17, cell surface associated 0.0281325
GPHN gephyrin 0.0280368
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0279174
NCOR2 nuclear receptor corepressor 2 0.0277473
NCOR1 nuclear receptor corepressor 1 0.0272443
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0271049
PTBP3 polypyrimidine tract binding protein 3 0.0270569
EXOC1 exocyst complex component 1 0.0270096
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0270084
PLS1 plastin 1 0.0269228
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0267626
MED13L mediator complex subunit 13-like 0.0265722
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0261443

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.206
TPT1 tumor protein, translationally-controlled 1 -0.147326
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0824949
ONECUT3 one cut homeobox 3 -0.0798096
VCL vinculin -0.0762508
RPS6 ribosomal protein S6 -0.0697985
TMSB10 thymosin beta 10 -0.0677491
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0608562
RPL35A ribosomal protein L35a -0.0564487
RPL34 ribosomal protein L34 -0.0559251
RPLP1 ribosomal protein, large, P1 -0.0555249
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0525497
RPS8 ribosomal protein S8 -0.0502975
EXT1 exostosin glycosyltransferase 1 -0.0457649
PTMA prothymosin, alpha -0.04514
RPL23 ribosomal protein L23 -0.044
RPS24 ribosomal protein S24 -0.0432165
KLF5 Kruppel-like factor 5 (intestinal) -0.0420923
RPLP2 ribosomal protein, large, P2 -0.0401618
ACTG1 actin gamma 1 -0.0391249
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0361682
FTL ferritin, light polypeptide -0.0361288
RPL26 ribosomal protein L26 -0.0357552
RPLP0 ribosomal protein, large, P0 -0.0334818
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0332955
RPL12 ribosomal protein L12 -0.0332291
KLF6 Kruppel-like factor 6 -0.0331097
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0327546
RPL9 ribosomal protein L9 -0.0322564
RPS27A ribosomal protein S27a -0.0319355
RPS12 ribosomal protein S12 -0.0309038
EIF1 eukaryotic translation initiation factor 1 -0.0308707
RPL36 ribosomal protein L36 -0.0303841
RPS19 ribosomal protein S19 -0.0299742
RPL31 ribosomal protein L31 -0.029004
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0283394
ARF1 ADP-ribosylation factor 1 -0.0282034
KDM3A lysine (K)-specific demethylase 3A -0.0281777
RTN3 reticulon 3 -0.0280017
IARS1 isoleucyl-tRNA synthetase 1 -0.0269955
CANX calnexin -0.0269181
RPL19 ribosomal protein L19 -0.0268627
RPS21 ribosomal protein S21 -0.0267726
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0265516
AHNAK AHNAK nucleoprotein -0.0262688
IER3 immediate early response 3 -0.02612
RPL37A ribosomal protein L37a -0.0259663
RPL30 ribosomal protein L30 -0.0249868
SQSTM1 sequestosome 1 -0.024934
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0249303
AGR2 anterior gradient 2 -0.0246011
RPS20 ribosomal protein S20 -0.024011
RPS3 ribosomal protein S3 -0.0239798
RPL5 ribosomal protein L5 -0.0233139
RPS29 ribosomal protein S29 -0.0232522
RPL38 ribosomal protein L38 -0.0232155
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0231804
RPL35 ribosomal protein L35 -0.0231742
HMGB1 high mobility group box 1 -0.0231419
CCND1 cyclin D1 -0.0230067
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0228956
RPL37 ribosomal protein L37 -0.0228728
RBM39 RNA binding motif protein 39 -0.0228604
RPL32 ribosomal protein L32 -0.0227104
GARS1 glycyl-tRNA synthetase 1 -0.0226674
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0223922
RPS13 ribosomal protein S13 -0.0222754
MYO1E myosin IE -0.0221687
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.022042
SMYD3 SET and MYND domain containing 3 -0.0219074
RRBP1 ribosome binding protein 1 -0.0218543
PDLIM5 PDZ and LIM domain 5 -0.0214657
RIGI RNA sensor RIG-I -0.021435
H1-0 H1.0 linker histone -0.0213665
RPL11 ribosomal protein L11 -0.0213567
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0210734
NPR2 natriuretic peptide receptor 2 -0.0210599
RPS25 ribosomal protein S25 -0.0209738
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.020748
S100A10 S100 calcium binding protein A10 -0.0207255
RPL27A ribosomal protein L27a -0.0205382
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0203701
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0202561
MYO1D myosin ID -0.0202276
RPL13A ribosomal protein L13a -0.0199602
NEBL nebulette -0.0198348
ANKRD10 ankyrin repeat domain 10 -0.0197817
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0195699
SENP5 SUMO1/sentrin specific peptidase 5 -0.0195561
SLC38A2 solute carrier family 38, member 2 -0.0195273
FUS FUS RNA binding protein -0.0191989
BZW1 basic leucine zipper and W2 domains 1 -0.0187302
MTAP methylthioadenosine phosphorylase -0.0186391
FHIT fragile histidine triad -0.0184968
NCEH1 neutral cholesterol ester hydrolase 1 -0.0181208
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0179969
ISG15 ISG15 ubiquitin-like modifier -0.0179649
LPP LIM domain containing preferred translocation partner in lipoma -0.0177541
UBE2B ubiquitin-conjugating enzyme E2B -0.0177183
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.017627