Zileuton_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Zileuton perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Zileuton_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.268676
PDE4D phosphodiesterase 4D, cAMP-specific 0.16475
THSD4 thrombospondin, type I, domain containing 4 0.142886
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.130955
EGFR epidermal growth factor receptor 0.113424
PTPRM protein tyrosine phosphatase, receptor type, M 0.10857
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0985232
MCL1 myeloid cell leukemia 1 0.0943478
LAMA4 laminin, alpha 4 0.079978
DOCK5 dedicator of cytokinesis 5 0.0791767
INTS6 integrator complex subunit 6 0.0748147
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.072357
EFNA5 ephrin-A5 0.0710859
PDLIM5 PDZ and LIM domain 5 0.0690728
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0661496
CAV1 caveolin 1, caveolae protein, 22kDa 0.0655304
ERRFI1 ERBB receptor feedback inhibitor 1 0.0646459
FTH1 ferritin, heavy polypeptide 1 0.0640181
VCL vinculin 0.0604712
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0569459
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0564675
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0540246
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.053268
ANXA2 annexin A2 0.0525347
CXCL8 chemokine (C-X-C motif) ligand 8 0.0492026
DSPP dentin sialophosphoprotein 0.0488188
LMO7 LIM domain 7 0.0484319
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0477155
ZSWIM6 zinc finger, SWIM-type containing 6 0.047537
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.047495
MYO1E myosin IE 0.0458234
EGR1 early growth response 1 0.0456359
MAML3 mastermind-like 3 (Drosophila) 0.0454934
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0452951
VMP1 vacuole membrane protein 1 0.0443363
TMSB10 thymosin beta 10 0.0437196
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0435447
LDHA lactate dehydrogenase A 0.0425422
MT2A metallothionein 2A 0.0421791
ACTG1 actin gamma 1 0.0419387
AREG amphiregulin 0.0414506
OSMR oncostatin M receptor 0.041408
LPP LIM domain containing preferred translocation partner in lipoma 0.0405799
POTEF POTE ankyrin domain family, member F 0.0403522
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0395366
SCEL sciellin 0.0393694
MACF1 microtubule-actin crosslinking factor 1 0.0387314
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0384932
FNDC3A fibronectin type III domain containing 3A 0.0367633
LGALS12 lectin, galactoside-binding, soluble, 12 0.0366186
AKAP12 A kinase (PRKA) anchor protein 12 0.0346138
S100A10 S100 calcium binding protein A10 0.0340493
BCAR3 breast cancer anti-estrogen resistance 3 0.0338889
PM20D1 peptidase M20 domain containing 1 0.0338864
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0321192
ASPH aspartate beta-hydroxylase 0.0320984
FOXP1 forkhead box P1 0.0319688
AKAP13 A kinase (PRKA) anchor protein 13 0.0315646
ANXA1 annexin A1 0.0314249
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0313712
DNER delta/notch-like EGF repeat containing 0.0313096
GRAMD1B GRAM domain containing 1B 0.0312686
SAMD4A sterile alpha motif domain containing 4A 0.030952
SLC38A2 solute carrier family 38, member 2 0.0307341
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0304115
TRIP12 thyroid hormone receptor interactor 12 0.0294791
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0293392
ELL2 elongation factor, RNA polymerase II, 2 0.0289657
CAV2 caveolin 2 0.0289183
NTN4 netrin 4 0.0288083
NCOA3 nuclear receptor coactivator 3 0.0287732
NSUN6 NOP2/Sun domain family, member 6 0.0282043
TRAPPC9 trafficking protein particle complex 9 0.0281359
FRY furry homolog (Drosophila) 0.0279351
CUX1 cut-like homeobox 1 0.0271999
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0269949
DOCK1 dedicator of cytokinesis 1 0.0265567
CST3 cystatin C 0.0262519
ENO1 enolase 1, (alpha) 0.0262394
EPAS1 endothelial PAS domain protein 1 0.0260638
RAB10 RAB10, member RAS oncogene family 0.026008
LRP1B low density lipoprotein receptor-related protein 1B 0.025643
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0255078
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0253435
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0251365
OXSR1 oxidative stress responsive 1 0.0250809
BMP6 bone morphogenetic protein 6 0.0249253
HOMER1 homer scaffolding protein 1 0.0249136
ATP11A ATPase, class VI, type 11A 0.0248848
RIMS2 regulating synaptic membrane exocytosis 2 0.0247819
RCOR1 REST corepressor 1 0.0247598
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0247077
PKM pyruvate kinase, muscle 0.0246968
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0245879
CCSER1 coiled-coil serine-rich protein 1 0.0242025
RABGAP1L RAB GTPase activating protein 1-like 0.0238701
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0238305
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0237594
JMJD1C jumonji domain containing 1C 0.023587
RERE arginine-glutamic acid dipeptide (RE) repeats 0.023471

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.149276
NDRG1 N-myc downstream regulated 1 -0.0841501
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0649448
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0640651
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.060832
NAMPT nicotinamide phosphoribosyltransferase -0.053133
CAMTA1 calmodulin binding transcription activator 1 -0.0531281
NGLY1 N-glycanase 1 -0.0505645
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0468477
TMEM165 transmembrane protein 165 -0.0447183
PGK1 phosphoglycerate kinase 1 -0.0429507
TBC1D22A TBC1 domain family, member 22A -0.0411581
ANKRD10 ankyrin repeat domain 10 -0.0356138
SQSTM1 sequestosome 1 -0.0348051
SMAD3 SMAD family member 3 -0.0346499
PRRC2C proline-rich coiled-coil 2C -0.0341391
ANKRD12 ankyrin repeat domain 12 -0.0339351
WDR45B WD repeat domain 45B -0.0336092
RBM39 RNA binding motif protein 39 -0.0331767
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0323603
GLS2 glutaminase 2 (liver, mitochondrial) -0.0320379
OGA O-GlcNAcase -0.0314314
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0309943
KMT2E lysine (K)-specific methyltransferase 2E -0.0307597
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0306446
ZNF292 zinc finger protein 292 -0.0304772
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0289496
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.028664
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.027764
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0274631
LAMB3 laminin, beta 3 -0.0273292
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0264908
UVRAG UV radiation resistance associated -0.0261649
SLMAP sarcolemma associated protein -0.0258709
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0247128
KCMF1 potassium channel modulatory factor 1 -0.0245667
NDE1 nudE neurodevelopment protein 1 -0.0245665
KDM2A lysine (K)-specific demethylase 2A -0.0243681
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0242695
BRWD1 bromodomain and WD repeat domain containing 1 -0.0241011
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0240504
USP9X ubiquitin specific peptidase 9, X-linked -0.0236781
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0236053
RAP1B RAP1B, member of RAS oncogene family -0.0232284
AGO2 argonaute RISC catalytic component 2 -0.0229696
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0229323
FAM13A family with sequence similarity 13, member A -0.0229085
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0228702
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0227983
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0226436
HOOK2 hook microtubule-tethering protein 2 -0.0225586
H1-0 H1.0 linker histone -0.0220814
KDM3A lysine (K)-specific demethylase 3A -0.0219738
AKR1C1 aldo-keto reductase family 1, member C1 -0.0217654
ADAM17 ADAM metallopeptidase domain 17 -0.021626
UBE2O ubiquitin-conjugating enzyme E2O -0.0216073
ZFC3H1 zinc finger, C3H1-type containing -0.0213376
MARF1 meiosis regulator and mRNA stability factor 1 -0.0212671
CANX calnexin -0.0210131
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0209426
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0206911
ABLIM1 actin binding LIM protein 1 -0.0206581
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.020652
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0205021
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0204964
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0204333
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.0204061
PNISR PNN-interacting serine/arginine-rich protein -0.0202488
NUP58 nucleoporin 58 -0.0201577
RAB27B RAB27B, member RAS oncogene family -0.0201407
ADGRF1 adhesion G protein-coupled receptor F1 -0.019986
RAB1A RAB1A, member RAS oncogene family -0.0198982
MATR3 matrin 3 -0.0195574
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0195383
ZC3H15 zinc finger CCCH-type containing 15 -0.0193111
ATG14 autophagy related 14 -0.019214
YEATS2 YEATS domain containing 2 -0.0189704
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0188473
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.018818
BTG1 B-cell translocation gene 1, anti-proliferative -0.0188172
TENT5A terminal nucleotidyltransferase 5A -0.0187257
ZC3H11A zinc finger CCCH-type containing 11A -0.0186902
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.018599
SEPTIN2 septin 2 -0.018406
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0183516
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.018344
CAB39 calcium binding protein 39 -0.0180326
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0178163
TNRC6A trinucleotide repeat containing 6A -0.0177846
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0177421
ZFAND6 zinc finger, AN1-type domain 6 -0.0177139
FNIP1 folliculin interacting protein 1 -0.0174808
ZFR zinc finger RNA binding protein -0.0174484
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0173292
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0173045
GIGYF2 GRB10 interacting GYF protein 2 -0.0170843
TMEM39A transmembrane protein 39A -0.0170331
RNMT RNA (guanine-7-) methyltransferase -0.0169949
ARRDC3 arrestin domain containing 3 -0.0169581
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0167562