Zileuton_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Zileuton perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Zileuton_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.107365
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.106095
FNDC3B fibronectin type III domain containing 3B 0.0702881
NPC1 Niemann-Pick disease, type C1 0.0652174
ZEB2 zinc finger E-box binding homeobox 2 0.0552017
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0550505
PDE4D phosphodiesterase 4D, cAMP-specific 0.0545412
OSMR oncostatin M receptor 0.0527462
EFNA5 ephrin-A5 0.0499288
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0485141
DOCK5 dedicator of cytokinesis 5 0.0466334
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0457661
ADD3 adducin 3 (gamma) 0.0445091
SMAD3 SMAD family member 3 0.0440036
RAB27B RAB27B, member RAS oncogene family 0.0433889
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0421918
ARHGAP5 Rho GTPase activating protein 5 0.0412755
PELI1 pellino E3 ubiquitin protein ligase 1 0.0375802
CTNND1 catenin (cadherin-associated protein), delta 1 0.0356584
DSCAM Down syndrome cell adhesion molecule 0.0344172
BMAL2 basic helix-loop-helix ARNT like 2 0.0336521
ZC3H12C zinc finger CCCH-type containing 12C 0.033511
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0329195
OGA O-GlcNAcase 0.0323488
NRP1 neuropilin 1 0.0321626
GLCCI1 glucocorticoid induced 1 0.0299595
USP34 ubiquitin specific peptidase 34 0.0298631
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0297081
NAV2 neuron navigator 2 0.0293318
CD44 CD44 molecule (Indian blood group) 0.0292621
KYNU kynureninase 0.0287442
PRELID2 PRELI domain containing 2 0.0282534
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.028056
VMP1 vacuole membrane protein 1 0.0279451
STK38L serine/threonine kinase 38 like 0.0274778
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0272501
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0266708
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0265688
SAMD4A sterile alpha motif domain containing 4A 0.0261526
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0256782
RUNX2 runt-related transcription factor 2 0.0253883
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0253517
MEIS1 Meis homeobox 1 0.024789
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0246919
RNF149 ring finger protein 149 0.0246342
TRIO trio Rho guanine nucleotide exchange factor 0.0244522
EGFR epidermal growth factor receptor 0.0240461
STRN3 striatin, calmodulin binding protein 3 0.0238478
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0236709
TPST1 tyrosylprotein sulfotransferase 1 0.0230463
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0227001
CAB39 calcium binding protein 39 0.0226148
ANKRD36 ankyrin repeat domain 36 0.02239
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0222738
PID1 phosphotyrosine interaction domain containing 1 0.0222028
HAS2 hyaluronan synthase 2 0.0215295
FAM3C family with sequence similarity 3, member C 0.0214962
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0213802
AGFG1 ArfGAP with FG repeats 1 0.0213639
FAM20C family with sequence similarity 20, member C 0.0211034
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0210928
ATP13A3 ATPase type 13A3 0.0210658
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0208809
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0208354
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0205695
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0205493
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0204646
TGM2 transglutaminase 2 0.0203991
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0203277
BACE2 beta-site APP-cleaving enzyme 2 0.0202132
NGLY1 N-glycanase 1 0.0201323
VRK2 vaccinia related kinase 2 0.0201289
CEP95 centrosomal protein 95kDa 0.0198675
CFDP1 craniofacial development protein 1 0.0198345
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0195939
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0193907
SPRED1 sprouty-related, EVH1 domain containing 1 0.0193222
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0190667
AOPEP aminopeptidase O (putative) 0.0189334
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.018789
PRKCSH protein kinase C substrate 80K-H 0.0186561
RARB retinoic acid receptor, beta 0.0185988
PCNX1 pecanex 1 0.0185311
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0185015
ZBTB20 zinc finger and BTB domain containing 20 0.0184266
DUSP5 dual specificity phosphatase 5 0.0184099
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0184008
FBXL13 F-box and leucine-rich repeat protein 13 0.0183994
NCOA7 nuclear receptor coactivator 7 0.0183636
GCC2 GRIP and coiled-coil domain containing 2 0.0182251
DPYSL3 dihydropyrimidinase-like 3 0.0180584
ARHGAP42 Rho GTPase activating protein 42 0.018015
ATXN10 ataxin 10 0.0178577
METTL15 methyltransferase like 15 0.0176654
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0176535
ZFC3H1 zinc finger, C3H1-type containing 0.0175306
CDK17 cyclin-dependent kinase 17 0.0175211
ITCH itchy E3 ubiquitin protein ligase 0.0174966
LRRC49 leucine rich repeat containing 49 0.0173294
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0172631

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.181833
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.177453
FN1 fibronectin 1 -0.130426
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105419
TMSB10 thymosin beta 10 -0.101602
FTL ferritin, light polypeptide -0.0887493
PTMA prothymosin, alpha -0.0869529
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0735605
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0715724
CDH13 cadherin 13 -0.0640388
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0619379
RPLP1 ribosomal protein, large, P1 -0.0616425
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0612808
IGFBP3 insulin-like growth factor binding protein 3 -0.0568073
NDRG1 N-myc downstream regulated 1 -0.056758
DDIT3 DNA-damage-inducible transcript 3 -0.0557157
FTH1 ferritin, heavy polypeptide 1 -0.0553978
RPS6 ribosomal protein S6 -0.0524776
GRB10 growth factor receptor-bound protein 10 -0.0502373
RPS8 ribosomal protein S8 -0.0492368
B2M beta-2-microglobulin -0.048963
PKM pyruvate kinase, muscle -0.0475781
RIOK3 RIO kinase 3 -0.047534
PCBP2 poly(rC) binding protein 2 -0.0461683
RPS19 ribosomal protein S19 -0.0458838
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0452446
EGR1 early growth response 1 -0.044864
HMGA1 high mobility group AT-hook 1 -0.0442346
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0440096
MEF2A myocyte enhancer factor 2A -0.0439459
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0438865
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.042371
STC1 stanniocalcin 1 -0.0422696
RPS12 ribosomal protein S12 -0.0418718
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0416454
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0415776
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0415534
RPL23 ribosomal protein L23 -0.0410779
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0408802
NAP1L1 nucleosome assembly protein 1-like 1 -0.0406429
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0397879
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0385996
CA12 carbonic anhydrase XII -0.0380594
S100A6 S100 calcium binding protein A6 -0.0377735
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0377049
DST dystonin -0.0374769
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0358674
RAB1A RAB1A, member RAS oncogene family -0.035679
LOX lysyl oxidase -0.0356585
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0354547
KTN1 kinectin 1 (kinesin receptor) -0.0353433
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0352871
IER3 immediate early response 3 -0.0351125
RPL34 ribosomal protein L34 -0.0340124
RPL35A ribosomal protein L35a -0.033742
HILPDA hypoxia inducible lipid droplet-associated -0.0335019
ENO1 enolase 1, (alpha) -0.0327539
TGFB1 transforming growth factor, beta 1 -0.0326681
RPL32 ribosomal protein L32 -0.0326644
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0323068
YBX1 Y box binding protein 1 -0.0318759
RPL36 ribosomal protein L36 -0.0317192
RAB7A RAB7A, member RAS oncogene family -0.0316161
POTEF POTE ankyrin domain family, member F -0.0315053
RPL37A ribosomal protein L37a -0.0313109
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.031145
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0309665
MTSS1 metastasis suppressor 1 -0.0308175
LDHA lactate dehydrogenase A -0.0306163
EIF1 eukaryotic translation initiation factor 1 -0.0304758
S100A10 S100 calcium binding protein A10 -0.0301286
PDIA3 protein disulfide isomerase family A, member 3 -0.0301242
TMSB4X thymosin beta 4, X-linked -0.0298647
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0294852
RPL37 ribosomal protein L37 -0.0294503
RPS3 ribosomal protein S3 -0.0293444
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0292896
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0290185
GNAS GNAS complex locus -0.0289255
RPL31 ribosomal protein L31 -0.0288964
ASPH aspartate beta-hydroxylase -0.0283469
PDGFA platelet-derived growth factor alpha polypeptide -0.0279513
MAP1B microtubule-associated protein 1B -0.0279028
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0277523
RPL11 ribosomal protein L11 -0.0271922
SQSTM1 sequestosome 1 -0.0270403
TFPI2 tissue factor pathway inhibitor 2 -0.026584
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0264624
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0263857
LOC102724023 ES1 protein homolog, mitochondrial -0.026292
RPS29 ribosomal protein S29 -0.0259051
CALR calreticulin -0.0259002
EEF2 eukaryotic translation elongation factor 2 -0.0257647
RACK1 receptor for activated C kinase 1 -0.0257444
LOC112694756 uncharaterized LOC112694756 -0.0256821
RPL12 ribosomal protein L12 -0.0255031
MT2A metallothionein 2A -0.0249421
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0248791
RPLP2 ribosomal protein, large, P2 -0.024499
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0242436