| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Zileuton perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Zileuton_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.197026 |
| PM20D1 | peptidase M20 domain containing 1 | 0.19447 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.181344 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0909681 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0785223 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0644412 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0606492 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0505661 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0464679 |
| DOCK4 | dedicator of cytokinesis 4 | 0.046058 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0454794 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0454075 |
| VMP1 | vacuole membrane protein 1 | 0.0396468 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0392844 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0359347 |
| PDE8A | phosphodiesterase 8A | 0.035856 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0337691 |
| MCL1 | myeloid cell leukemia 1 | 0.0334731 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0318453 |
| NNMT | nicotinamide N-methyltransferase | 0.0313903 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0307104 |
| USP34 | ubiquitin specific peptidase 34 | 0.0300055 |
| ATXN1 | ataxin 1 | 0.0296674 |
| ATP11A | ATPase, class VI, type 11A | 0.0296579 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0267101 |
| OSMR | oncostatin M receptor | 0.0266806 |
| CFDP1 | craniofacial development protein 1 | 0.0265606 |
| RPL4 | ribosomal protein L4 | 0.0257 |
| WWOX | WW domain containing oxidoreductase | 0.0256509 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0253531 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0250261 |
| MKI67 | marker of proliferation Ki-67 | 0.0246464 |
| PRKCE | protein kinase C, epsilon | 0.0244083 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0240564 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0237221 |
| BMP6 | bone morphogenetic protein 6 | 0.0236849 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0235722 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0235303 |
| KIAA0319 | KIAA0319 | 0.0232677 |
| NTN4 | netrin 4 | 0.0232638 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0232533 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0227794 |
| SNX14 | sorting nexin 14 | 0.0223506 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0218738 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0217596 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0215813 |
| CENPF | centromere protein F, 350/400kDa | 0.0214899 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0213434 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0209547 |
| JMJD1C | jumonji domain containing 1C | 0.0204747 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0204345 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0204343 |
| CMIP | c-Maf inducing protein | 0.0204198 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0202851 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0202098 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0201345 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0197707 |
| NPC1 | Niemann-Pick disease, type C1 | 0.019566 |
| CENPE | centromere protein E, 312kDa | 0.0193586 |
| PFKP | phosphofructokinase, platelet | 0.0191968 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0190724 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0190309 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0187702 |
| EXOC6B | exocyst complex component 6B | 0.0187423 |
| MFF | mitochondrial fission factor | 0.0186643 |
| FAM107B | family with sequence similarity 107, member B | 0.0184631 |
| WDR59 | WD repeat domain 59 | 0.0182836 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0181424 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0179527 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0178827 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0177843 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0172848 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0169318 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0168615 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0167645 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0164796 |
| KYNU | kynureninase | 0.0161913 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0160549 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0157869 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0156152 |
| NF1 | neurofibromin 1 | 0.0155023 |
| PRKD1 | protein kinase D1 | 0.0154632 |
| SMYD3 | SET and MYND domain containing 3 | 0.0149715 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0148667 |
| GAN | gigaxonin | 0.0147433 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0146413 |
| FAM3C | family with sequence similarity 3, member C | 0.0144663 |
| TCIM | transcriptional and immune response regulator | 0.0144281 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0143479 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0142441 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.014188 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0141028 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0140948 |
| FHL2 | four and a half LIM domains 2 | 0.0140474 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.013967 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0139501 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0139278 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0138558 |
| CBFB | core-binding factor, beta subunit | 0.0138172 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0138066 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.143911 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0840722 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0834309 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0816186 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0744595 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0655898 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0654495 |
| FTL | ferritin, light polypeptide | -0.05291 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0467506 |
| RBM39 | RNA binding motif protein 39 | -0.0447769 |
| ZNF292 | zinc finger protein 292 | -0.0440321 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0440152 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0438703 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0428996 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0416768 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.039448 |
| PTMA | prothymosin, alpha | -0.0391269 |
| PARD3 | par-3 family cell polarity regulator | -0.0382992 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0380533 |
| RPL23 | ribosomal protein L23 | -0.0377892 |
| NRG1 | neuregulin 1 | -0.0376625 |
| YBX1 | Y box binding protein 1 | -0.0370751 |
| IGF2 | insulin-like growth factor 2 | -0.0362206 |
| RBM25 | RNA binding motif protein 25 | -0.0341749 |
| RLF | rearranged L-myc fusion | -0.0334303 |
| ANXA1 | annexin A1 | -0.0333707 |
| USP3 | ubiquitin specific peptidase 3 | -0.0330797 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0325795 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0314553 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0311655 |
| HMGA1 | high mobility group AT-hook 1 | -0.0305907 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0301723 |
| TFG | TRK-fused gene | -0.029959 |
| RBM8A | RNA binding motif protein 8A | -0.0297353 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0296537 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0294619 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0293726 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0292286 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.029054 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0288354 |
| RPL37A | ribosomal protein L37a | -0.0286425 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0285892 |
| JUN | jun proto-oncogene | -0.0281925 |
| CALR | calreticulin | -0.0280372 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0272824 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0267649 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0267612 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | -0.0266452 |
| IER3 | immediate early response 3 | -0.0266442 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0265346 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0257852 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0255789 |
| STC1 | stanniocalcin 1 | -0.0253384 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0252738 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0252358 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | -0.0252158 |
| YBX3 | Y box binding protein 3 | -0.0251071 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.024752 |
| PTK2 | protein tyrosine kinase 2 | -0.0247497 |
| TMSB10 | thymosin beta 10 | -0.0246573 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0246356 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0242551 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.023854 |
| WDR43 | WD repeat domain 43 | -0.0238276 |
| PKM | pyruvate kinase, muscle | -0.0238192 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | -0.0237953 |
| FLNB | filamin B, beta | -0.0236092 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0235859 |
| APP | amyloid beta (A4) precursor protein | -0.0234481 |
| THBS1 | thrombospondin 1 | -0.0234245 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0232206 |
| RPS6 | ribosomal protein S6 | -0.0231726 |
| WAC | WW domain containing adaptor with coiled-coil | -0.023118 |
| PCBP2 | poly(rC) binding protein 2 | -0.0231131 |
| CAVIN1 | caveolae associated protein 1 | -0.0230384 |
| MTMR3 | myotubularin related protein 3 | -0.0226405 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0224573 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0224238 |
| NEGR1 | neuronal growth regulator 1 | -0.0221964 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0221187 |
| NOP58 | NOP58 ribonucleoprotein | -0.0215553 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0214583 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0214332 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0213636 |
| RNF145 | ring finger protein 145 | -0.0212888 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0210805 |
| TMEM87A | transmembrane protein 87A | -0.0208281 |
| LMNA | lamin A/C | -0.0207693 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0206147 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0205354 |
| TPM3 | tropomyosin 3 | -0.0204789 |
| ZNF207 | zinc finger protein 207 | -0.0202867 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0201455 |
| FUS | FUS RNA binding protein | -0.020104 |
| RPL36 | ribosomal protein L36 | -0.0197606 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.0197512 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0196817 |
| CLU | clusterin | -0.0195533 |
| MTF2 | metal response element binding transcription factor 2 | -0.0193579 |
| HMGB1 | high mobility group box 1 | -0.0193082 |
