| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Zileuton perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Zileuton_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0960601 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0724655 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0652058 |
| SMAD3 | SMAD family member 3 | 0.0545161 |
| RAD51B | RAD51 paralog B | 0.0476567 |
| GRAMD1B | GRAM domain containing 1B | 0.0470921 |
| POTEF | POTE ankyrin domain family, member F | 0.0425683 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0407254 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0393222 |
| HMGA2 | high mobility group AT-hook 2 | 0.0380697 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.033167 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0320701 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0311826 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0299954 |
| TXNRD1 | thioredoxin reductase 1 | 0.0295194 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0293272 |
| VMP1 | vacuole membrane protein 1 | 0.0287981 |
| EGFR | epidermal growth factor receptor | 0.0287363 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0283424 |
| AHNAK | AHNAK nucleoprotein | 0.0264821 |
| PDE10A | phosphodiesterase 10A | 0.0262212 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.025814 |
| EXOC4 | exocyst complex component 4 | 0.0257459 |
| RNF213 | ring finger protein 213 | 0.0251303 |
| RPL4 | ribosomal protein L4 | 0.0249342 |
| CLIC1 | chloride intracellular channel 1 | 0.0245418 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0242388 |
| VCL | vinculin | 0.0236017 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0233384 |
| OSMR | oncostatin M receptor | 0.0222621 |
| KRT8 | keratin 8, type II | 0.0220327 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0217252 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0214753 |
| LATS2 | large tumor suppressor kinase 2 | 0.0209636 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0209409 |
| PHF21A | PHD finger protein 21A | 0.020317 |
| MMP12 | matrix metallopeptidase 12 | 0.0198198 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0197305 |
| RFX7 | regulatory factor X, 7 | 0.019567 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0188969 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0186805 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0185733 |
| COPA | coatomer protein complex, subunit alpha | 0.0179674 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0179175 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0178897 |
| FAM13A | family with sequence similarity 13, member A | 0.0177798 |
| ZNF462 | zinc finger protein 462 | 0.0175416 |
| RIGI | RNA sensor RIG-I | 0.0171273 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0170545 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0170219 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0167163 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0163648 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0163624 |
| EHBP1 | EH domain binding protein 1 | 0.016353 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0163112 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.01596 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0158632 |
| PHF14 | PHD finger protein 14 | 0.0158321 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0157929 |
| TPM4 | tropomyosin 4 | 0.0155816 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0155503 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0155395 |
| FMNL2 | formin-like 2 | 0.0154762 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0154657 |
| TUBB | tubulin, beta class I | 0.0154329 |
| FNBP4 | formin binding protein 4 | 0.0153514 |
| PLS3 | plastin 3 | 0.0152812 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0152136 |
| RGS17 | regulator of G-protein signaling 17 | 0.0152008 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0151817 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0149512 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0140749 |
| PYGL | phosphorylase, glycogen, liver | 0.0140251 |
| TRERF1 | transcriptional regulating factor 1 | 0.0138618 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0138607 |
| TAPBP | TAP binding protein (tapasin) | 0.0138592 |
| SMIM44 | small integral membrane protein 44 | 0.0137724 |
| FNDC3B | fibronectin type III domain containing 3B | 0.013697 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0134503 |
| R3HDM2 | R3H domain containing 2 | 0.0133318 |
| NFIA | nuclear factor I/A | 0.013288 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0131106 |
| RHBDD1 | rhomboid domain containing 1 | 0.0130639 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0129459 |
| LOXL2 | lysyl oxidase-like 2 | 0.0128996 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0128133 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.012751 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0126995 |
| MYOF | myoferlin | 0.0125442 |
| SRBD1 | S1 RNA binding domain 1 | 0.0124989 |
| NVL | nuclear VCP-like | 0.0124768 |
| MSI2 | musashi RNA-binding protein 2 | 0.0124539 |
| PFKP | phosphofructokinase, platelet | 0.0123818 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0123049 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.0122566 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0120173 |
| ODF2L | outer dense fiber of sperm tails 2-like | 0.0118555 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0118527 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0117664 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0117216 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.190125 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.108418 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.101171 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0928403 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0868391 |
| PTMA | prothymosin, alpha | -0.0835867 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0816678 |
| YBX3 | Y box binding protein 3 | -0.0796926 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0790207 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0688611 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0630415 |
| RBM39 | RNA binding motif protein 39 | -0.0629117 |
| RPL37A | ribosomal protein L37a | -0.0602973 |
| RPS8 | ribosomal protein S8 | -0.0547787 |
| RPL37 | ribosomal protein L37 | -0.054573 |
| RPS12 | ribosomal protein S12 | -0.0545298 |
| RPL38 | ribosomal protein L38 | -0.0540606 |
| RTN4 | reticulon 4 | -0.0523795 |
| RPL26 | ribosomal protein L26 | -0.0520486 |
| RPS2 | ribosomal protein S2 | -0.0512925 |
| TPI1 | triosephosphate isomerase 1 | -0.0496776 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0496559 |
| TMSB10 | thymosin beta 10 | -0.0470451 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0467581 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0451101 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.044627 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.044276 |
| STK4 | serine/threonine kinase 4 | -0.0438482 |
| SEPTIN7 | septin 7 | -0.0432678 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0431591 |
| RPS6 | ribosomal protein S6 | -0.0428203 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0420341 |
| RPS19 | ribosomal protein S19 | -0.0410752 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0409202 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.040764 |
| RPLP1 | ribosomal protein, large, P1 | -0.0405138 |
| RPS3 | ribosomal protein S3 | -0.039892 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0396481 |
| RPS15 | ribosomal protein S15 | -0.0390218 |
| RPS21 | ribosomal protein S21 | -0.0387983 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0377413 |
| RPL23 | ribosomal protein L23 | -0.0376569 |
| RPL9 | ribosomal protein L9 | -0.0373073 |
| RPL19 | ribosomal protein L19 | -0.0369882 |
| CLTC | clathrin, heavy chain (Hc) | -0.0368374 |
| RPS10 | ribosomal protein S10 | -0.0357552 |
| FBXO11 | F-box protein 11 | -0.0357213 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0354569 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0350296 |
| RPL12 | ribosomal protein L12 | -0.0349397 |
| PFDN2 | prefoldin subunit 2 | -0.0349167 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.034843 |
| RPLP0 | ribosomal protein, large, P0 | -0.0338025 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0336969 |
| RPS29 | ribosomal protein S29 | -0.0334068 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0330438 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0326047 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0323749 |
| GOLGA4 | golgin A4 | -0.0321453 |
| MORF4L2 | mortality factor 4 like 2 | -0.031813 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0316687 |
| RPLP2 | ribosomal protein, large, P2 | -0.0316257 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0314714 |
| GOLGB1 | golgin B1 | -0.0311415 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0310155 |
| MCL1 | myeloid cell leukemia 1 | -0.0308616 |
| UBC | ubiquitin C | -0.030529 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0299815 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0295513 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0294534 |
| LRRC23 | leucine rich repeat containing 23 | -0.0293475 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0292727 |
| RPL31 | ribosomal protein L31 | -0.0291013 |
| HLA-B | major histocompatibility complex, class I, B | -0.0290093 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0284776 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0284418 |
| BRD2 | bromodomain containing 2 | -0.0283961 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0282584 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0280868 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0278297 |
| TPM3 | tropomyosin 3 | -0.0277851 |
| PHIP | pleckstrin homology domain interacting protein | -0.0276737 |
| RPL36 | ribosomal protein L36 | -0.0276472 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0273735 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0272331 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0271219 |
| RACK1 | receptor for activated C kinase 1 | -0.027035 |
| RPS17 | ribosomal protein S17 | -0.0269859 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0269472 |
| GOLT1B | golgi transport 1B | -0.0267187 |
| RECQL | RecQ helicase-like | -0.0265358 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0263358 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0262892 |
| RAB10 | RAB10, member RAS oncogene family | -0.0262518 |
| SPAG9 | sperm associated antigen 9 | -0.0262426 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.025753 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0254372 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0253777 |
| CBX3 | chromobox homolog 3 | -0.0253762 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0252034 |
