| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Zileuton perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Zileuton_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | 0.0931545 |
| POTEF | POTE ankyrin domain family, member F | 0.0860635 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0706712 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0668524 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0625739 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0620507 |
| ANXA2 | annexin A2 | 0.0548573 |
| TMSB10 | thymosin beta 10 | 0.0528726 |
| KRT8 | keratin 8, type II | 0.0499267 |
| LAMB3 | laminin, beta 3 | 0.0498344 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0475609 |
| LMO7 | LIM domain 7 | 0.0454652 |
| FTL | ferritin, light polypeptide | 0.0449037 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0419466 |
| TOP1 | topoisomerase (DNA) I | 0.0402598 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0383276 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0357767 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0336125 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0325277 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0319945 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0301311 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.030039 |
| CLIC1 | chloride intracellular channel 1 | 0.0296878 |
| SDC4 | syndecan 4 | 0.0294234 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0284515 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0279952 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0273322 |
| KLF6 | Kruppel-like factor 6 | 0.026921 |
| CSTB | cystatin B (stefin B) | 0.0264722 |
| KRT7 | keratin 7, type II | 0.0264528 |
| ACTG1 | actin gamma 1 | 0.0260461 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0258734 |
| CTSB | cathepsin B | 0.0254251 |
| HLA-A | major histocompatibility complex, class I, A | 0.0250144 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0243142 |
| GNAS | GNAS complex locus | 0.0240444 |
| PGK1 | phosphoglycerate kinase 1 | 0.0232511 |
| RPL4 | ribosomal protein L4 | 0.0226855 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0222787 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0220061 |
| COPA | coatomer protein complex, subunit alpha | 0.0218549 |
| FNBP1L | formin binding protein 1-like | 0.021813 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0217743 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0212637 |
| AHNAK | AHNAK nucleoprotein | 0.0211887 |
| PLAU | plasminogen activator, urokinase | 0.0211478 |
| BCL2L1 | BCL2-like 1 | 0.0209724 |
| F11R | F11 receptor | 0.0204717 |
| FAM13A | family with sequence similarity 13, member A | 0.0203842 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0200621 |
| WASF2 | WAS protein family, member 2 | 0.0198813 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0198148 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0193292 |
| MSI2 | musashi RNA-binding protein 2 | 0.0189137 |
| RNF145 | ring finger protein 145 | 0.0188189 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0183042 |
| RPL35A | ribosomal protein L35a | 0.0178561 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0178131 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0177843 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0177682 |
| FAM162A | family with sequence similarity 162, member A | 0.0176271 |
| H1-0 | H1.0 linker histone | 0.0176233 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0174245 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 0.0172946 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0167377 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.016635 |
| TP53BP2 | tumor protein p53 binding protein 2 | 0.0165346 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0165041 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0162824 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0162175 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.016195 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0159011 |
| JUN | jun proto-oncogene | 0.015754 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0155829 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0155387 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.015476 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0153793 |
| MCU | mitochondrial calcium uniporter | 0.0151689 |
| TTC9 | tetratricopeptide repeat domain 9 | 0.0150665 |
| MORF4L1 | mortality factor 4 like 1 | 0.0149256 |
| CAVIN1 | caveolae associated protein 1 | 0.0148595 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0148323 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0145822 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0145089 |
| TMEM123 | transmembrane protein 123 | 0.0144945 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0143512 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0143403 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0142946 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0142595 |
| PRRC1 | proline-rich coiled-coil 1 | 0.01404 |
| IRF6 | interferon regulatory factor 6 | 0.0140141 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0139463 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0138821 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0138643 |
| FAM3C | family with sequence similarity 3, member C | 0.0138448 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0137108 |
| CD2AP | CD2-associated protein | 0.0135785 |
| ARF1 | ADP-ribosylation factor 1 | 0.0134881 |
| S100A10 | S100 calcium binding protein A10 | 0.0134673 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0134634 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.186055 |
| NDRG1 | N-myc downstream regulated 1 | -0.15316 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.138508 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.106153 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0833906 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0813075 |
| GOLGA4 | golgin A4 | -0.0812286 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0809217 |
| RPS6 | ribosomal protein S6 | -0.0780066 |
| ASPH | aspartate beta-hydroxylase | -0.0720718 |
| FN1 | fibronectin 1 | -0.0719352 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0719205 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0686747 |
| RPS2 | ribosomal protein S2 | -0.0660182 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0611286 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0556703 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0538253 |
| RPL9 | ribosomal protein L9 | -0.052821 |
| TXNRD1 | thioredoxin reductase 1 | -0.0523467 |
| RPL7 | ribosomal protein L7 | -0.0517532 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0501388 |
| PTMA | prothymosin, alpha | -0.0500856 |
| MSN | moesin | -0.0495248 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.049 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.048912 |
| MKI67 | marker of proliferation Ki-67 | -0.0483612 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0481641 |
| RPS3 | ribosomal protein S3 | -0.0473841 |
| TPM3 | tropomyosin 3 | -0.0471896 |
| RPS12 | ribosomal protein S12 | -0.0469276 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0461364 |
| NAV2 | neuron navigator 2 | -0.0460645 |
| FBXO32 | F-box protein 32 | -0.0458263 |
| PAPOLA | poly(A) polymerase alpha | -0.0457342 |
| SQSTM1 | sequestosome 1 | -0.0438878 |
| RPL37A | ribosomal protein L37a | -0.0437581 |
| RPLP2 | ribosomal protein, large, P2 | -0.0430571 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0414324 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0406198 |
| CENPF | centromere protein F, 350/400kDa | -0.0404969 |
| UBC | ubiquitin C | -0.0403957 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0402618 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0402522 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | -0.0401434 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0401434 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0381123 |
| CLTC | clathrin, heavy chain (Hc) | -0.0372431 |
| RPL19 | ribosomal protein L19 | -0.0369601 |
| HMGB2 | high mobility group box 2 | -0.0367249 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0366604 |
| CCNL1 | cyclin L1 | -0.0365543 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0359726 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0354179 |
| RPS8 | ribosomal protein S8 | -0.0354063 |
| CANX | calnexin | -0.0353563 |
| RPL11 | ribosomal protein L11 | -0.0351552 |
| RPS13 | ribosomal protein S13 | -0.035039 |
| RPL32 | ribosomal protein L32 | -0.0348287 |
| RPS23 | ribosomal protein S23 | -0.0346403 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0338245 |
| DSPP | dentin sialophosphoprotein | -0.0337245 |
| RPS17 | ribosomal protein S17 | -0.0333821 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0329446 |
| SET | SET nuclear proto-oncogene | -0.0327194 |
| DSTN | destrin (actin depolymerizing factor) | -0.0323394 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0322908 |
| ADAR | adenosine deaminase, RNA-specific | -0.0321766 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0318242 |
| LAMC2 | laminin, gamma 2 | -0.0316898 |
| PCBP2 | poly(rC) binding protein 2 | -0.0316841 |
| FHIT | fragile histidine triad | -0.0314977 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0313622 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0313217 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0312532 |
| RBM25 | RNA binding motif protein 25 | -0.0312217 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0312146 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0311792 |
| RPS27A | ribosomal protein S27a | -0.0309856 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0309436 |
| PKM | pyruvate kinase, muscle | -0.0306586 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0305722 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.0305271 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0304234 |
| MYO6 | myosin VI | -0.0304174 |
| BBX | bobby sox homolog (Drosophila) | -0.0302079 |
| HMGA1 | high mobility group AT-hook 1 | -0.0300427 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0297803 |
| ERBIN | erbb2 interacting protein | -0.0295144 |
| RBM39 | RNA binding motif protein 39 | -0.0294243 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0292858 |
| RPL15 | ribosomal protein L15 | -0.0290036 |
| UPP1 | uridine phosphorylase 1 | -0.0290019 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0282247 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0279532 |
| RPL5 | ribosomal protein L5 | -0.0278747 |
| ARRDC3 | arrestin domain containing 3 | -0.0278665 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.027774 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0275766 |
| TMSB4X | thymosin beta 4, X-linked | -0.02752 |
| RPL38 | ribosomal protein L38 | -0.0275075 |
