Zileuton_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Zileuton perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Zileuton_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GDA guanine deaminase 0.207467
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.160189
PM20D1 peptidase M20 domain containing 1 0.125168
EFNA5 ephrin-A5 0.114447
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0869581
NAMPT nicotinamide phosphoribosyltransferase 0.084217
DST dystonin 0.0801943
NEK7 NIMA-related kinase 7 0.0695062
CD109 CD109 molecule 0.0669784
ZEB2 zinc finger E-box binding homeobox 2 0.0664446
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0640014
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0638967
KYNU kynureninase 0.0630177
CTSC cathepsin C 0.0625163
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0623426
COL5A2 collagen, type V, alpha 2 0.0619787
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0614415
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0606567
GRAMD1B GRAM domain containing 1B 0.0604152
TXNRD1 thioredoxin reductase 1 0.0596916
NPAS2 neuronal PAS domain protein 2 0.0569915
NRCAM neuronal cell adhesion molecule 0.0555804
SAMD4A sterile alpha motif domain containing 4A 0.0550252
COL8A1 collagen, type VIII, alpha 1 0.0543067
LIMCH1 LIM and calponin homology domains 1 0.053448
PCBP3 poly(rC) binding protein 3 0.0507253
COL4A6 collagen, type IV, alpha 6 0.0489234
BCAR3 breast cancer anti-estrogen resistance 3 0.0485351
MFF mitochondrial fission factor 0.0478404
FNDC3B fibronectin type III domain containing 3B 0.047607
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0465754
ELL2 elongation factor, RNA polymerase II, 2 0.0461734
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0456075
ASPH aspartate beta-hydroxylase 0.0455737
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0444627
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0417491
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0399863
TBXT T-box transcription factor T 0.0396414
MCL1 myeloid cell leukemia 1 0.0379306
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0377562
PTEN phosphatase and tensin homolog 0.0376583
ARHGAP29 Rho GTPase activating protein 29 0.0374602
TGFBI transforming growth factor, beta-induced, 68kDa 0.0367771
TFPI2 tissue factor pathway inhibitor 2 0.0366778
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0360058
ESYT2 extended synaptotagmin-like protein 2 0.0350367
PDLIM5 PDZ and LIM domain 5 0.0348123
COL4A5 collagen, type IV, alpha 5 0.03373
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0334439
VMP1 vacuole membrane protein 1 0.0323362
GPRIN3 GPRIN family member 3 0.0322862
CENPF centromere protein F, 350/400kDa 0.0321042
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0319372
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0318131
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0309875
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0307796
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0306978
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.030213
ITPRID2 ITPR interacting domain containing 2 0.0301865
AVL9 AVL9 homolog (S. cerevisiase) 0.0291241
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0284493
TMX4 thioredoxin-related transmembrane protein 4 0.0282266
MKI67 marker of proliferation Ki-67 0.0275423
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.027148
AGFG1 ArfGAP with FG repeats 1 0.0267221
ANKRD28 ankyrin repeat domain 28 0.0263539
TRIO trio Rho guanine nucleotide exchange factor 0.0255683
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0249509
WWTR1 WW domain containing transcription regulator 1 0.0246995
PYGL phosphorylase, glycogen, liver 0.0241989
RAB3B RAB3B, member RAS oncogene family 0.0237563
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0236177
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0235547
ENAH enabled homolog (Drosophila) 0.0234172
FN1 fibronectin 1 0.0230304
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0225678
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0222279
TNPO1 transportin 1 0.0221778
MALT1 MALT1 paracaspase 0.0220517
WDFY2 WD repeat and FYVE domain containing 2 0.0217813
OSMR oncostatin M receptor 0.0217151
DPYD dihydropyrimidine dehydrogenase 0.0216804
NTN4 netrin 4 0.021243
RPL4 ribosomal protein L4 0.0209114
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0208612
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0206939
DNER delta/notch-like EGF repeat containing 0.0203568
PTGR1 prostaglandin reductase 1 0.020189
RPL3 ribosomal protein L3 0.0201781
CDK17 cyclin-dependent kinase 17 0.0199962
CARD16 caspase recruitment domain family, member 16 0.0198362
SEPTIN10 septin 10 0.0196815
ZBTB38 zinc finger and BTB domain containing 38 0.0188314
BDNF brain-derived neurotrophic factor 0.0187634
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0186115
IL1RAP interleukin 1 receptor accessory protein 0.0184473
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0183899
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0181697
ZC3H12C zinc finger CCCH-type containing 12C 0.018152
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0180672

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.194006
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.162681
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.158204
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.147171
PDE4D phosphodiesterase 4D, cAMP-specific -0.130265
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0964942
TMSB10 thymosin beta 10 -0.0961047
TPT1 tumor protein, translationally-controlled 1 -0.0888054
CDH13 cadherin 13 -0.0800997
RPS6 ribosomal protein S6 -0.07961
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0767847
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0725027
LSAMP limbic system-associated membrane protein -0.070412
RPLP1 ribosomal protein, large, P1 -0.0699911
PRKN parkin RBR E3 ubiquitin protein ligase -0.0663326
PTMA prothymosin, alpha -0.0620892
FTL ferritin, light polypeptide -0.0605883
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0592743
VIM vimentin -0.0559578
RPL37A ribosomal protein L37a -0.0523618
ADGRD1 adhesion G protein-coupled receptor D1 -0.0517615
PTPRM protein tyrosine phosphatase, receptor type, M -0.0515301
NAP1L1 nucleosome assembly protein 1-like 1 -0.050728
RPS8 ribosomal protein S8 -0.0501115
RPS24 ribosomal protein S24 -0.0495383
WARS1 tryptophanyl-tRNA synthetase 1 -0.0489943
SQSTM1 sequestosome 1 -0.0482252
RPS19 ribosomal protein S19 -0.0481986
RPL26 ribosomal protein L26 -0.0465355
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0442187
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0436007
RPL35A ribosomal protein L35a -0.0429767
RPL19 ribosomal protein L19 -0.0415424
RPL31 ribosomal protein L31 -0.0413916
RPL23 ribosomal protein L23 -0.0409188
ACTG1 actin gamma 1 -0.0390892
NALF1 NALCN channel auxiliary factor 1 -0.0383185
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0381403
NCKAP5 NCK-associated protein 5 -0.0380532
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0378428
RPS23 ribosomal protein S23 -0.03649
DENND1A DENN/MADD domain containing 1A -0.0362711
RPS27A ribosomal protein S27a -0.0350403
ANTXR1 anthrax toxin receptor 1 -0.0348784
RPS21 ribosomal protein S21 -0.0338913
CADM2 cell adhesion molecule 2 -0.0338704
P3H2 prolyl 3-hydroxylase 2 -0.0334034
PRELID2 PRELI domain containing 2 -0.0330607
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0326276
RPS12 ribosomal protein S12 -0.0326249
RPL9 ribosomal protein L9 -0.0324219
CTBP2 C-terminal binding protein 2 -0.0322769
RPL38 ribosomal protein L38 -0.0315366
RPL12 ribosomal protein L12 -0.0312474
RPL34 ribosomal protein L34 -0.0311465
PCDH15 protocadherin-related 15 -0.0310528
RPL37 ribosomal protein L37 -0.0310417
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0308917
RPLP0 ribosomal protein, large, P0 -0.0304535
MORF4L2 mortality factor 4 like 2 -0.0304167
CUX1 cut-like homeobox 1 -0.030279
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.030235
RPS29 ribosomal protein S29 -0.0302344
S100A10 S100 calcium binding protein A10 -0.0302052
SOD2 superoxide dismutase 2, mitochondrial -0.0299778
AEBP2 AE binding protein 2 -0.0294982
RPLP2 ribosomal protein, large, P2 -0.0294328
RPS16 ribosomal protein S16 -0.0292095
PKM pyruvate kinase, muscle -0.0289408
RPL36 ribosomal protein L36 -0.0288842
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0286357
LMNA lamin A/C -0.0284351
OASL 2'-5'-oligoadenylate synthetase-like -0.0280719
SPAG9 sperm associated antigen 9 -0.0279085
B2M beta-2-microglobulin -0.0278682
GNAS GNAS complex locus -0.0278317
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0277486
XYLT1 xylosyltransferase I -0.0276138
RPL11 ribosomal protein L11 -0.0273313
AUTS2 autism susceptibility candidate 2 -0.0273234
MAP7 microtubule-associated protein 7 -0.0272246
KIAA0825 KIAA0825 -0.0270043
RPS3 ribosomal protein S3 -0.0269261
CANX calnexin -0.0268413
INTS6 integrator complex subunit 6 -0.0265473
NT5C2 5'-nucleotidase, cytosolic II -0.0264168
RPL13A ribosomal protein L13a -0.025835
RAB7A RAB7A, member RAS oncogene family -0.0257535
RPL7A ribosomal protein L7a -0.0255333
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0254447
NCOR2 nuclear receptor corepressor 2 -0.025383
PDE7B phosphodiesterase 7B -0.0253564
RAD51B RAD51 paralog B -0.0248778
RPS25 ribosomal protein S25 -0.0248254
YBX3 Y box binding protein 3 -0.0244641
RPS27 ribosomal protein S27 -0.0243377
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0242469
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0241044
FOXK1 forkhead box K1 -0.0234521
RACK1 receptor for activated C kinase 1 -0.0233087