| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Zileuton perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Zileuton_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.126647 |
| FMN1 | formin 1 | 0.111675 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.111579 |
| COPA | coatomer protein complex, subunit alpha | 0.105412 |
| PRRC2C | proline-rich coiled-coil 2C | 0.101462 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.089834 |
| MYO1E | myosin IE | 0.089644 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0891949 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0869493 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0830495 |
| EGFR | epidermal growth factor receptor | 0.0801342 |
| TOP1 | topoisomerase (DNA) I | 0.0797488 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0792901 |
| ASPH | aspartate beta-hydroxylase | 0.0791265 |
| SMAD3 | SMAD family member 3 | 0.0782784 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0773436 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.074522 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0713921 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0681985 |
| SMYD3 | SET and MYND domain containing 3 | 0.0666367 |
| PRKCA | protein kinase C, alpha | 0.0653508 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0620301 |
| COG5 | component of oligomeric golgi complex 5 | 0.0604709 |
| CDK6 | cyclin-dependent kinase 6 | 0.059982 |
| FN1 | fibronectin 1 | 0.0579909 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0571933 |
| ETNK1 | ethanolamine kinase 1 | 0.0559924 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0556156 |
| USP34 | ubiquitin specific peptidase 34 | 0.0552158 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0541524 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0538531 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0534993 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0524676 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0510878 |
| PARD3 | par-3 family cell polarity regulator | 0.0505952 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0503643 |
| PRELID2 | PRELI domain containing 2 | 0.0488232 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0454089 |
| MCL1 | myeloid cell leukemia 1 | 0.0449239 |
| NUP98 | nucleoporin 98kDa | 0.0444859 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0443573 |
| ANXA2 | annexin A2 | 0.0441744 |
| ZNF609 | zinc finger protein 609 | 0.0439394 |
| GPC6 | glypican 6 | 0.0421817 |
| CANX | calnexin | 0.040985 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0408782 |
| AHNAK | AHNAK nucleoprotein | 0.0407247 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0397356 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0393788 |
| YTHDC1 | YTH domain containing 1 | 0.0390059 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0383475 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0377382 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0377117 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0374678 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.037186 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0365533 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0337395 |
| TMSB10 | thymosin beta 10 | 0.0336983 |
| FTL | ferritin, light polypeptide | 0.033624 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0334581 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0326965 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0320751 |
| RPL34 | ribosomal protein L34 | 0.0313247 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0311228 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0309769 |
| EHBP1 | EH domain binding protein 1 | 0.0299169 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0291292 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0287871 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0283224 |
| BBX | bobby sox homolog (Drosophila) | 0.0282476 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0279242 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0276749 |
| FAM13A | family with sequence similarity 13, member A | 0.0264267 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0258132 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0254855 |
| RPS16 | ribosomal protein S16 | 0.0247348 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0244523 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0233708 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0230392 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.020952 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0204477 |
| TXNIP | thioredoxin interacting protein | 0.0199039 |
| RSL24D1 | ribosomal L24 domain containing 1 | 0.0196083 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0194258 |
| NF1 | neurofibromin 1 | 0.0194161 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0185369 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0184667 |
| NFIA | nuclear factor I/A | 0.0178802 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0174656 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.01714 |
| CUX1 | cut-like homeobox 1 | 0.0169717 |
| KIAA1958 | KIAA1958 | 0.0161898 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0161151 |
| CLINT1 | clathrin interactor 1 | 0.0157429 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0151573 |
| KIF5B | kinesin family member 5B | 0.014571 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.014359 |
| SLTM | SAFB-like, transcription modulator | 0.0142357 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0138853 |
| DIAPH1 | diaphanous-related formin 1 | 0.0137216 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.153478 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.110469 |
| DSCAM | Down syndrome cell adhesion molecule | -0.10912 |
| RPS8 | ribosomal protein S8 | -0.107991 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.104923 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.104155 |
| SPAG9 | sperm associated antigen 9 | -0.0960017 |
| LAMA4 | laminin, alpha 4 | -0.094805 |
| PTMA | prothymosin, alpha | -0.0931697 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0904446 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0859408 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0855484 |
| RPS6 | ribosomal protein S6 | -0.0831664 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0803775 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0796659 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0741975 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0734551 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0692091 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0684148 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0663683 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0660897 |
| FNIP1 | folliculin interacting protein 1 | -0.0655603 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0649722 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0641354 |
| RPLP1 | ribosomal protein, large, P1 | -0.0633157 |
| ACTG1 | actin gamma 1 | -0.0603439 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.057321 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0569868 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0558781 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0547366 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0521414 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0518676 |
| SBF2 | SET binding factor 2 | -0.0501485 |
| JMJD1C | jumonji domain containing 1C | -0.0499648 |
| RORA | RAR-related orphan receptor A | -0.0494534 |
| ZNF292 | zinc finger protein 292 | -0.0481877 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0468883 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0464624 |
| GOLGB1 | golgin B1 | -0.0463404 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0452498 |
| VIM | vimentin | -0.0441597 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0434458 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0430902 |
| RBM39 | RNA binding motif protein 39 | -0.0428288 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.042283 |
| STC1 | stanniocalcin 1 | -0.0407541 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.040007 |
| EXT1 | exostosin glycosyltransferase 1 | -0.039196 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0385505 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0384501 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0380332 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0374111 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0361727 |
| RSF1 | remodeling and spacing factor 1 | -0.0342928 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0339821 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0328473 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0321433 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0317111 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0316632 |
| USP53 | ubiquitin specific peptidase 53 | -0.0299745 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0279944 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0277113 |
| RAB10 | RAB10, member RAS oncogene family | -0.0267985 |
| VMP1 | vacuole membrane protein 1 | -0.0256677 |
| MT2A | metallothionein 2A | -0.0253629 |
| CD2AP | CD2-associated protein | -0.0252793 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0244212 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0241768 |
| STAG2 | stromal antigen 2 | -0.0240754 |
| ABI1 | abl-interactor 1 | -0.0233002 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0229365 |
| CSNK2A2 | casein kinase 2, alpha prime polypeptide | -0.0219192 |
| ETFA | electron-transfer-flavoprotein, alpha polypeptide | -0.0215916 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.0214437 |
| ARGLU1 | arginine and glutamate rich 1 | -0.021214 |
| USP3 | ubiquitin specific peptidase 3 | -0.0211929 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0209744 |
| GPHN | gephyrin | -0.0205088 |
| DST | dystonin | -0.0204341 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0190574 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0189205 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0176399 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0175691 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.01708 |
| PKM | pyruvate kinase, muscle | -0.0161454 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0161112 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0160189 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0159703 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | -0.0156998 |
| RPL26 | ribosomal protein L26 | -0.0148642 |
| PTK2 | protein tyrosine kinase 2 | -0.0147093 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0141485 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0140282 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0127705 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0124091 |
| SEC24B | SEC24 family member B | -0.0108618 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0108432 |
| TJP1 | tight junction protein 1 | -0.00947321 |
| HDAC8 | histone deacetylase 8 | -0.00942969 |
| TMF1 | TATA element modulatory factor 1 | -0.0091659 |
