Zileuton_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Zileuton perturbation in SNU-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Zileuton_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.113307
TXNRD1 thioredoxin reductase 1 0.110107
ADAM10 ADAM metallopeptidase domain 10 0.109425
TJP1 tight junction protein 1 0.0954691
VCL vinculin 0.0778461
FLNB filamin B, beta 0.0675475
TMEM65 transmembrane protein 65 0.061497
SMYD3 SET and MYND domain containing 3 0.0582709
EGFR epidermal growth factor receptor 0.057613
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0558983
PRELID2 PRELI domain containing 2 0.0553622
EFNA5 ephrin-A5 0.0547601
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0544952
PYGB phosphorylase, glycogen; brain 0.0530781
HDAC9 histone deacetylase 9 0.050592
SBF2 SET binding factor 2 0.0502396
NBEA neurobeachin 0.0500287
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0490865
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0479832
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0465047
PDGFC platelet derived growth factor C 0.0463508
ANK2 ankyrin 2, neuronal 0.0453231
ZBTB20 zinc finger and BTB domain containing 20 0.0449381
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0448489
PICALM phosphatidylinositol binding clathrin assembly protein 0.0433744
SOX6 SRY (sex determining region Y)-box 6 0.0429212
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0422581
DSCAM Down syndrome cell adhesion molecule 0.0420662
GOLGA4 golgin A4 0.0414983
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0411303
MINDY2 MINDY lysine 48 deubiquitinase 2 0.040856
SAMD4A sterile alpha motif domain containing 4A 0.0408156
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0389723
EZR ezrin 0.0373324
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0371966
ZNF608 zinc finger protein 608 0.0370484
EEF2 eukaryotic translation elongation factor 2 0.0370188
LPP LIM domain containing preferred translocation partner in lipoma 0.036272
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.035323
EXT1 exostosin glycosyltransferase 1 0.0346875
RTN4 reticulon 4 0.0342765
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.033988
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0338261
LDHA lactate dehydrogenase A 0.0329351
NBAS neuroblastoma amplified sequence 0.0320504
SLC38A2 solute carrier family 38, member 2 0.0312204
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0307747
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0304971
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0303752
TBC1D22A TBC1 domain family, member 22A 0.0299758
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0297116
ATP9B ATPase, class II, type 9B 0.0296655
METTL15 methyltransferase like 15 0.0295359
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0295016
ANKRD17 ankyrin repeat domain 17 0.0294541
TBC1D5 TBC1 domain family, member 5 0.0294279
RHBDD1 rhomboid domain containing 1 0.0294082
JMJD1C jumonji domain containing 1C 0.0293588
NCEH1 neutral cholesterol ester hydrolase 1 0.0289611
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.028697
RPL3 ribosomal protein L3 0.0277423
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0276006
TGFBR3 transforming growth factor, beta receptor III 0.0271094
TTC3 tetratricopeptide repeat domain 3 0.0261932
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0260554
AKAP9 A kinase (PRKA) anchor protein 9 0.0258669
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0256489
FNDC3B fibronectin type III domain containing 3B 0.0255956
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0253182
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0250926
ZCCHC7 zinc finger, CCHC domain containing 7 0.0250798
NFIA nuclear factor I/A 0.0250242
HDLBP high density lipoprotein binding protein 0.0250105
DOCK3 dedicator of cytokinesis 3 0.0247684
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0245764
PDE4B phosphodiesterase 4B, cAMP-specific 0.024574
CD47 CD47 molecule 0.0241222
KDM4C lysine (K)-specific demethylase 4C 0.0237172
DIAPH2 diaphanous-related formin 2 0.0234486
COG5 component of oligomeric golgi complex 5 0.0232216
FER fer (fps/fes related) tyrosine kinase 0.0231838
AHI1 Abelson helper integration site 1 0.0230731
ZNF638 zinc finger protein 638 0.023064
NF1 neurofibromin 1 0.0229887
NKTR natural killer cell triggering receptor 0.0221417
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0218424
ADNP activity-dependent neuroprotector homeobox 0.0218325
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0218078
PTPRG protein tyrosine phosphatase, receptor type, G 0.0216445
FAM91A1 family with sequence similarity 91, member A1 0.0215572
ZMYM2 zinc finger, MYM-type 2 0.0215525
BTBD9 BTB (POZ) domain containing 9 0.0213265
POTEF POTE ankyrin domain family, member F 0.0211036
RB1CC1 RB1-inducible coiled-coil 1 0.0210912
RAB27B RAB27B, member RAS oncogene family 0.0210783
YEATS2 YEATS domain containing 2 0.0210742
SREBF2 sterol regulatory element binding transcription factor 2 0.0209923
TTC28 tetratricopeptide repeat domain 28 0.0206192
PLXNA1 plexin A1 0.0205313
YAP1 Yes-associated protein 1 0.0203993

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.201962
BMP10 bone morphogenetic protein 10 -0.0862315
TPT1 tumor protein, translationally-controlled 1 -0.0782405
RPS8 ribosomal protein S8 -0.059671
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0543957
RPS6 ribosomal protein S6 -0.0512152
RPL35A ribosomal protein L35a -0.046209
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0457826
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0440226
RPL34 ribosomal protein L34 -0.0436231
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0384519
NAP1L1 nucleosome assembly protein 1-like 1 -0.0373277
MKI67 marker of proliferation Ki-67 -0.0372913
TOP2A topoisomerase (DNA) II alpha 170kDa -0.035332
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.03426
NAV2 neuron navigator 2 -0.0334765
DIAPH3 diaphanous-related formin 3 -0.0322225
RPLP2 ribosomal protein, large, P2 -0.0319401
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0313565
RPS27A ribosomal protein S27a -0.0310711
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0310258
SMC4 structural maintenance of chromosomes 4 -0.0305785
RPLP1 ribosomal protein, large, P1 -0.0301715
RPL31 ribosomal protein L31 -0.0294924
NAMPT nicotinamide phosphoribosyltransferase -0.029467
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0294551
CENPF centromere protein F, 350/400kDa -0.0291994
RPL23 ribosomal protein L23 -0.0282815
RPS3 ribosomal protein S3 -0.0282523
KPNB1 karyopherin (importin) beta 1 -0.0269083
RPS13 ribosomal protein S13 -0.0266808
RPL36 ribosomal protein L36 -0.0262505
RPS24 ribosomal protein S24 -0.0261791
RFC3 replication factor C (activator 1) 3, 38kDa -0.0258985
RPL9 ribosomal protein L9 -0.0258767
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0257726
RPL19 ribosomal protein L19 -0.0257289
HSPB1 heat shock 27kDa protein 1 -0.0249148
TPX2 TPX2, microtubule-associated -0.0243355
RPS19 ribosomal protein S19 -0.0240142
RPL37A ribosomal protein L37a -0.0239194
ANLN anillin, actin binding protein -0.023426
RPL26 ribosomal protein L26 -0.0227474
RPL32 ribosomal protein L32 -0.0225245
UNC13A unc-13 homolog A (C. elegans) -0.0221536
RPS25 ribosomal protein S25 -0.0220291
MYL12B myosin, light chain 12B, regulatory -0.0220196
SSBP2 single-stranded DNA binding protein 2 -0.0218138
RPL37 ribosomal protein L37 -0.0215756
LOC102724023 ES1 protein homolog, mitochondrial -0.0214668
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0213385
HMGB2 high mobility group box 2 -0.0200705
EMP3 epithelial membrane protein 3 -0.0197246
CENPE centromere protein E, 312kDa -0.0196586
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0194924
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0194271
RAD21 RAD21 homolog (S. pombe) -0.0188298
S100A4 S100 calcium binding protein A4 -0.0187796
FTL ferritin, light polypeptide -0.0186565
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0183897
RPL7A ribosomal protein L7a -0.0183616
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0175036
RPLP0 ribosomal protein, large, P0 -0.0174475
RRM2 ribonucleotide reductase M2 -0.0173435
KMT2E lysine (K)-specific methyltransferase 2E -0.0172742
B2M beta-2-microglobulin -0.0170432
RACK1 receptor for activated C kinase 1 -0.0169804
TUBB4B tubulin, beta 4B class IVb -0.0168407
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0167432
NOP58 NOP58 ribonucleoprotein -0.0164349
ATAD2 ATPase family, AAA domain containing 2 -0.0160746
ANXA1 annexin A1 -0.0160617
DEK DEK proto-oncogene -0.0158309
RPL11 ribosomal protein L11 -0.0158199
PRC1 protein regulator of cytokinesis 1 -0.0158117
HMGB1 high mobility group box 1 -0.0157625
PDE7B phosphodiesterase 7B -0.0157163
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0157014
S100A9 S100 calcium binding protein A9 -0.0156023
FUS FUS RNA binding protein -0.0155489
NUSAP1 nucleolar and spindle associated protein 1 -0.0155153
RPL18 ribosomal protein L18 -0.0154331
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0153179
SCLT1 sodium channel and clathrin linker 1 -0.0151977
RBM39 RNA binding motif protein 39 -0.0151394
RPL12 ribosomal protein L12 -0.015086
RPS21 ribosomal protein S21 -0.0150141
UBB ubiquitin B -0.0147288
RPS12 ribosomal protein S12 -0.0146642
GLI3 GLI family zinc finger 3 -0.014451
RPL38 ribosomal protein L38 -0.0143319
TMSB10 thymosin beta 10 -0.0142907
H3-3B H3.3 histone B -0.0142601
RPS23 ribosomal protein S23 -0.0141471
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0140941
RPS10 ribosomal protein S10 -0.013892
RPL8 ribosomal protein L8 -0.0138622
TPI1 triosephosphate isomerase 1 -0.0138047
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0137578
ELOVL5 ELOVL fatty acid elongase 5 -0.0136516