Zileuton_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Zileuton perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Zileuton_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0997831
FNDC3B fibronectin type III domain containing 3B 0.0844355
FN1 fibronectin 1 0.0694093
MSN moesin 0.0571729
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0566304
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0494285
ELL2 elongation factor, RNA polymerase II, 2 0.0492844
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0465879
ARRDC3 arrestin domain containing 3 0.0461098
VEGFA vascular endothelial growth factor A 0.0382414
MYOF myoferlin 0.0375865
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0375041
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0372077
TENT5A terminal nucleotidyltransferase 5A 0.0362932
MKI67 marker of proliferation Ki-67 0.0351987
VCL vinculin 0.0347334
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0340773
TXNIP thioredoxin interacting protein 0.0340185
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0337409
RTN4 reticulon 4 0.0333691
VMP1 vacuole membrane protein 1 0.0306908
CENPF centromere protein F, 350/400kDa 0.0306514
NAV2 neuron navigator 2 0.0296564
TNIP1 TNFAIP3 interacting protein 1 0.0276316
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0271375
IL1RAP interleukin 1 receptor accessory protein 0.0264903
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0261591
ZFP36L1 ZFP36 ring finger protein-like 1 0.0243878
FLNB filamin B, beta 0.0241757
MYH9 myosin, heavy chain 9, non-muscle 0.0241303
DUSP5 dual specificity phosphatase 5 0.024053
CKAP5 cytoskeleton associated protein 5 0.0235915
SBF2 SET binding factor 2 0.0232409
SMAD3 SMAD family member 3 0.0229361
COL8A1 collagen, type VIII, alpha 1 0.0225242
BCAR3 breast cancer anti-estrogen resistance 3 0.0223705
UBA6 ubiquitin-like modifier activating enzyme 6 0.022329
TAPBP TAP binding protein (tapasin) 0.0222812
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0218542
METTL15 methyltransferase like 15 0.0216053
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0215587
UGCG UDP-glucose ceramide glucosyltransferase 0.0215436
MX1 MX dynamin-like GTPase 1 0.0215432
TGM2 transglutaminase 2 0.0215279
PLPP3 phospholipid phosphatase 3 0.0209905
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0206564
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0206454
PLPP6 phospholipid phosphatase 6 0.0198042
NRIP1 nuclear receptor interacting protein 1 0.0194469
AHR aryl hydrocarbon receptor 0.019382
JMJD1C jumonji domain containing 1C 0.0192757
CCNL1 cyclin L1 0.0189812
FAM3C family with sequence similarity 3, member C 0.0188923
TGFB2 transforming growth factor, beta 2 0.018294
JAK2 Janus kinase 2 0.0181048
SYAP1 synapse associated protein 1 0.0177522
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0170432
MCL1 myeloid cell leukemia 1 0.0170305
RB1CC1 RB1-inducible coiled-coil 1 0.0168876
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0166075
DIAPH3 diaphanous-related formin 3 0.0162799
BIRC2 baculoviral IAP repeat containing 2 0.01626
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0160578
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0156998
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0156378
FBXL5 F-box and leucine-rich repeat protein 5 0.0155262
TNS3 tensin 3 0.0154602
NOTCH2 notch 2 0.0154535
CDK19 cyclin-dependent kinase 19 0.0153749
FAM219A family with sequence similarity 219, member A 0.0153738
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0153447
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.015284
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0146639
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0144517
ESYT2 extended synaptotagmin-like protein 2 0.0144006
USP47 ubiquitin specific peptidase 47 0.0143757
ZNF608 zinc finger protein 608 0.0143736
FRMD5 FERM domain containing 5 0.0143521
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0142425
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0140801
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0140261
ECPAS Ecm29 proteasome adaptor and scaffold 0.013913
ADNP activity-dependent neuroprotector homeobox 0.0135875
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.013529
CREB1 cAMP responsive element binding protein 1 0.0134122
ANKRD36 ankyrin repeat domain 36 0.0133987
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0133319
PPARD peroxisome proliferator-activated receptor delta 0.0133072
TXNRD1 thioredoxin reductase 1 0.0131158
RPL3 ribosomal protein L3 0.0130392
AXL AXL receptor tyrosine kinase 0.0129578
CDK17 cyclin-dependent kinase 17 0.0127949
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0127944
RIGI RNA sensor RIG-I 0.0127821
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0127645
HDAC9 histone deacetylase 9 0.0126855
ANO6 anoctamin 6 0.0126528
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0126476
BCLAF1 BCL2-associated transcription factor 1 0.0126011
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0125304

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.292185
TPT1 tumor protein, translationally-controlled 1 -0.167147
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.159262
IER3 immediate early response 3 -0.14905
HLA-B major histocompatibility complex, class I, B -0.146933
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.143623
CDH13 cadherin 13 -0.121317
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121002
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.119313
HMGA2 high mobility group AT-hook 2 -0.0997725
GLIS3 GLIS family zinc finger 3 -0.0948126
TMSB10 thymosin beta 10 -0.0901957
IGFBP3 insulin-like growth factor binding protein 3 -0.090166
RPS6 ribosomal protein S6 -0.0880519
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0858072
CANX calnexin -0.0838554
PGK1 phosphoglycerate kinase 1 -0.0836233
FTL ferritin, light polypeptide -0.0822398
NAP1L1 nucleosome assembly protein 1-like 1 -0.0801585
SQSTM1 sequestosome 1 -0.0782503
TMSB4X thymosin beta 4, X-linked -0.0729291
HLA-A major histocompatibility complex, class I, A -0.0725574
RPS8 ribosomal protein S8 -0.0669069
RPS24 ribosomal protein S24 -0.0668142
RPL23 ribosomal protein L23 -0.0643381
PTMA prothymosin, alpha -0.062664
RPL37A ribosomal protein L37a -0.0618978
CALR calreticulin -0.0610075
MT2A metallothionein 2A -0.060976
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0606481
SOD2 superoxide dismutase 2, mitochondrial -0.0596779
EIF1 eukaryotic translation initiation factor 1 -0.0567046
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0565132
AKAP12 A kinase (PRKA) anchor protein 12 -0.0556027
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0555889
RPS12 ribosomal protein S12 -0.0547878
RPL26 ribosomal protein L26 -0.0516164
BTG1 B-cell translocation gene 1, anti-proliferative -0.0507747
RPS3 ribosomal protein S3 -0.0496452
RPL35A ribosomal protein L35a -0.0492929
HLA-E major histocompatibility complex, class I, E -0.0490008
AFF3 AF4/FMR2 family, member 3 -0.0489021
GNAS GNAS complex locus -0.0478847
MORF4L2 mortality factor 4 like 2 -0.0460687
AHNAK AHNAK nucleoprotein -0.0458289
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0451912
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0450987
DIAPH2 diaphanous-related formin 2 -0.0450022
TRIO trio Rho guanine nucleotide exchange factor -0.044772
RPS23 ribosomal protein S23 -0.0446671
RPL19 ribosomal protein L19 -0.0439907
SLC38A1 solute carrier family 38, member 1 -0.0434841
CD44 CD44 molecule (Indian blood group) -0.0429665
RPLP1 ribosomal protein, large, P1 -0.0429501
ENO1 enolase 1, (alpha) -0.0428575
RPL36A ribosomal protein L36a -0.0428546
RPL9 ribosomal protein L9 -0.042534
KDM3A lysine (K)-specific demethylase 3A -0.0422135
EFNA5 ephrin-A5 -0.0413469
INTS6 integrator complex subunit 6 -0.0408423
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.039864
TMEM132D transmembrane protein 132D -0.0397543
RPLP2 ribosomal protein, large, P2 -0.0396908
RPL11 ribosomal protein L11 -0.0396752
MACF1 microtubule-actin crosslinking factor 1 -0.0389784
RPL12 ribosomal protein L12 -0.0387715
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0387691
LDHA lactate dehydrogenase A -0.0383475
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0383295
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0380817
RPS27A ribosomal protein S27a -0.0376417
RPL7A ribosomal protein L7a -0.0370439
ACTG1 actin gamma 1 -0.0359434
SOX5 SRY (sex determining region Y)-box 5 -0.0358988
RPLP0 ribosomal protein, large, P0 -0.0357924
RPL5 ribosomal protein L5 -0.0356415
WSB1 WD repeat and SOCS box containing 1 -0.0354563
RAI14 retinoic acid induced 14 -0.0354538
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0354139
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0347373
B2M beta-2-microglobulin -0.0336966
RACK1 receptor for activated C kinase 1 -0.0336745
PNRC1 proline-rich nuclear receptor coactivator 1 -0.03366
SFRP1 secreted frizzled-related protein 1 -0.0336343
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0335647
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0335116
RPS4X ribosomal protein S4, X-linked -0.033376
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0333659
IARS1 isoleucyl-tRNA synthetase 1 -0.0331497
RPL34 ribosomal protein L34 -0.0331006
ZFAND3 zinc finger, AN1-type domain 3 -0.0327284
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0326802
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0325201
COL5A1 collagen, type V, alpha 1 -0.0324011
PHF3 PHD finger protein 3 -0.0322692
CADM1 cell adhesion molecule 1 -0.0320924
ZMYND8 zinc finger, MYND-type containing 8 -0.032064
THBS2 thrombospondin 2 -0.0317087
RPL31 ribosomal protein L31 -0.0310047
RPL27A ribosomal protein L27a -0.0307715