| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms. (Chemical Entities of Biological Interest Ontology, CHEBI_10119) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/60854 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Ziprasidone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 2.13 |
| ZNF805 | zinc finger protein 805 | 1.68 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | 1.52 |
| SLC25A33 | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 | 1.05 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.94 |
| WDR24 | WD repeat domain 24 | 0.9 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.87 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.87 |
| SMO | smoothened, frizzled class receptor | 0.81 |
| BICRA | BRD4 interacting chromatin remodeling complex associated protein | 0.74 |
| TMSB10 | thymosin beta 10 | 0.73 |
| ZNF771 | zinc finger protein 771 | 0.72 |
| CEP89 | centrosomal protein 89kDa | 0.71 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.71 |
| FGB | fibrinogen beta chain | 0.71 |
| DBNL | drebrin-like | 0.69 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | 0.69 |
| WASF3 | WAS protein family, member 3 | 0.66 |
| CLTA | clathrin, light chain A | 0.65 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | 0.65 |
| TBC1D12 | TBC1 domain family, member 12 | 0.64 |
| HIST3H2BB | histone cluster 3, H2bb | 0.63 |
| EED | embryonic ectoderm development | 0.62 |
| MYZAP | myocardial zonula adherens protein | 0.62 |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.61 |
| SBF1 | SET binding factor 1 | 0.6 |
| HBA1 | hemoglobin, alpha 1 | 0.6 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.58 |
| FBXO17 | F-box protein 17 | 0.58 |
| ZGRF1 | zinc finger, GRF-type containing 1 | 0.57 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.56 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.56 |
| ZNF839 | zinc finger protein 839 | 0.55 |
| APOB | apolipoprotein B | 0.55 |
| ARFGEF3 | ARFGEF family member 3 | 0.55 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.54 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | 0.53 |
| THAP9 | THAP domain containing 9 | 0.52 |
| ZNF205 | zinc finger protein 205 | 0.51 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | 0.5 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.49 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | 0.49 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | 0.49 |
| UNC80 | unc-80 homolog (C. elegans) | 0.48 |
| SVBP | small vasohibin binding protein | 0.48 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.47 |
| TMEM173 | transmembrane protein 173 | 0.47 |
| EPHB3 | EPH receptor B3 | 0.47 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.47 |
| TNS2 | tensin 2 | 0.47 |
| RBMXL2 | RNA binding motif protein, X-linked-like 2 | 0.46 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.46 |
| CHM | choroideremia (Rab escort protein 1) | 0.45 |
| TMEM222 | transmembrane protein 222 | 0.45 |
| MAP2 | microtubule-associated protein 2 | 0.45 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.44 |
| KIAA0100 | KIAA0100 | 0.44 |
| RCE1 | Ras converting CAAX endopeptidase 1 | 0.44 |
| TMEM63A | transmembrane protein 63A | 0.44 |
| GON7 | GON7 subunit of KEOPS complex | 0.44 |
| BARD1 | BRCA1 associated RING domain 1 | 0.44 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.44 |
| USP27X | ubiquitin specific peptidase 27, X-linked | 0.43 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | 0.43 |
| ATXN1L | ataxin 1-like | 0.43 |
| APOE | apolipoprotein E | 0.43 |
| CUX1 | cut-like homeobox 1 | 0.43 |
| ATM | ATM serine/threonine kinase | 0.42 |
| ARMC7 | armadillo repeat containing 7 | 0.42 |
| RAB27B | RAB27B, member RAS oncogene family | 0.42 |
| SPEG | SPEG complex locus | 0.42 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | 0.42 |
| ZNF608 | zinc finger protein 608 | 0.42 |
| LDLRAP1 | low density lipoprotein receptor adaptor protein 1 | 0.42 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.42 |
| FAM8A1 | family with sequence similarity 8, member A1 | 0.42 |
| DDN | dendrin | 0.42 |
| KLHL20 | kelch-like family member 20 | 0.41 |
| OBSL1 | obscurin-like 1 | 0.41 |
| ZNF469 | zinc finger protein 469 | 0.41 |
| ANTXR1 | anthrax toxin receptor 1 | 0.41 |
| MAP1A | microtubule-associated protein 1A | 0.41 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.4 |
| LRRC28 | leucine rich repeat containing 28 | 0.4 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | 0.4 |
| ZC3HAV1L | zinc finger CCCH-type, antiviral 1-like | 0.4 |
| CMC2 | C-x(9)-C motif containing 2 | 0.4 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | 0.4 |
| ALDOA | aldolase A, fructose-bisphosphate | 0.4 |
| ZER1 | zyg-11 related, cell cycle regulator | 0.4 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | 0.4 |
| R3HDM4 | R3H domain containing 4 | 0.39 |
| PYM1 | PYM homolog 1, exon junction complex associated factor | 0.39 |
| CCDC91 | coiled-coil domain containing 91 | 0.39 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.39 |
| MTF1 | metal-regulatory transcription factor 1 | 0.39 |
| SNX29 | sorting nexin 29 | 0.39 |
| DAP | death-associated protein | 0.39 |
| PLEK | pleckstrin | 0.39 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -1.66 |
| MACC1 | metastasis associated in colon cancer 1 | -0.84 |
| QSOX2 | quiescin Q6 sulfhydryl oxidase 2 | -0.75 |
| CCDC112 | coiled-coil domain containing 112 | -0.74 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | -0.73 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.72 |
| TSNARE1 | t-SNARE domain containing 1 | -0.71 |
| PRAME | preferentially expressed antigen in melanoma | -0.68 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | -0.67 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.66 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.62 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.62 |
| GRTP1 | growth hormone regulated TBC protein 1 | -0.6 |
| ZNF483 | zinc finger protein 483 | -0.58 |
| ZKSCAN8 | zinc finger with KRAB and SCAN domains 8 | -0.58 |
| TOB2 | transducer of ERBB2, 2 | -0.54 |
| PDE9A | phosphodiesterase 9A | -0.53 |
| DUSP14 | dual specificity phosphatase 14 | -0.5 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.5 |
| MRPS18C | mitochondrial ribosomal protein S18C | -0.49 |
| ANGPTL4 | angiopoietin-like 4 | -0.49 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -0.49 |
| FAM117B | family with sequence similarity 117, member B | -0.48 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | -0.48 |
| KANK3 | KN motif and ankyrin repeat domains 3 | -0.47 |
| ERCC6 | excision repair cross-complementation group 6 | -0.46 |
| FNTA | farnesyltransferase, CAAX box, alpha | -0.45 |
| ANKRD12 | ankyrin repeat domain 12 | -0.45 |
| DST | dystonin | -0.44 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.44 |
| LYRM1 | LYR motif containing 1 | -0.44 |
| MCEE | methylmalonyl CoA epimerase | -0.44 |
| ASNSD1 | asparagine synthetase domain containing 1 | -0.44 |
| TTLL7 | tubulin tyrosine ligase-like family member 7 | -0.44 |
| CALU | calumenin | -0.43 |
| RAET1G | retinoic acid early transcript 1G | -0.42 |
| UNC5B | unc-5 homolog B (C. elegans) | -0.42 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.42 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.41 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.41 |
| CERS2 | ceramide synthase 2 | -0.41 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.41 |
| MOB3A | MOB kinase activator 3A | -0.4 |
| SBSN | suprabasin | -0.4 |
| SON | SON DNA binding protein | -0.39 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | -0.39 |
| PRRC1 | proline-rich coiled-coil 1 | -0.39 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | -0.39 |
| TRIM23 | tripartite motif containing 23 | -0.39 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.38 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | -0.38 |
| BLOC1S6 | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin | -0.38 |
| RNF139 | ring finger protein 139 | -0.38 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.37 |
| FAM86B2 | family with sequence similarity 86, member B2 | -0.37 |
| PDE7A | phosphodiesterase 7A | -0.37 |
| MKRN1 | makorin ring finger protein 1 | -0.36 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.36 |
| ZNF302 | zinc finger protein 302 | -0.36 |
| SPATA2 | spermatogenesis associated 2 | -0.35 |
| MEX3A | mex-3 RNA binding family member A | -0.35 |
| PLSCR3 | phospholipid scramblase 3 | -0.35 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.35 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -0.35 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.34 |
| ZNF219 | zinc finger protein 219 | -0.34 |
| RAB3B | RAB3B, member RAS oncogene family | -0.34 |
| EGR1 | early growth response 1 | -0.34 |
| CILP2 | cartilage intermediate layer protein 2 | -0.34 |
| GUCD1 | guanylyl cyclase domain containing 1 | -0.34 |
| MID2 | midline 2 | -0.34 |
| CERS6 | ceramide synthase 6 | -0.33 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | -0.33 |
| KIAA0556 | KIAA0556 | -0.33 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.33 |
| NDRG2 | NDRG family member 2 | -0.33 |
| SFXN4 | sideroflexin 4 | -0.33 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.33 |
| TRAPPC10 | trafficking protein particle complex 10 | -0.33 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.32 |
| SDC1 | syndecan 1 | -0.32 |
| NFIA | nuclear factor I/A | -0.32 |
| CCDC9B | coiled-coil domain containing 9B | -0.32 |
| RPP14 | ribonuclease P/MRP 14kDa subunit | -0.31 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | -0.31 |
| FBLL1 | fibrillarin-like 1 | -0.31 |
| NAPB | N-ethylmaleimide-sensitive factor attachment protein, beta | -0.31 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | -0.3 |
| RNFT2 | ring finger protein, transmembrane 2 | -0.3 |
| EOGT | EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase | -0.3 |
| AMD1 | adenosylmethionine decarboxylase 1 | -0.3 |
| RAB22A | RAB22A, member RAS oncogene family | -0.3 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.3 |
| DENND4B | DENN/MADD domain containing 4B | -0.29 |
| BRCC3 | BRCA1/BRCA2-containing complex, subunit 3 | -0.29 |
| DFFB | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | -0.29 |
| ARF3 | ADP-ribosylation factor 3 | -0.29 |
| LAMP1 | lysosomal-associated membrane protein 1 | -0.29 |
