| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position. (Chemical Entities of Biological Interest Ontology, CHEBI_10127) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5734 |
| Similar Terms | |
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199 proteins with high or low expression in Zonisamide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MIIP | migration and invasion inhibitory protein | 0.65 |
| MACC1 | metastasis associated in colon cancer 1 | 0.45 |
| CERCAM | cerebral endothelial cell adhesion molecule | 0.43 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | 0.43 |
| LMOD1 | leiomodin 1 (smooth muscle) | 0.42 |
| ZNF276 | zinc finger protein 276 | 0.42 |
| DAP | death-associated protein | 0.41 |
| DPYD | dihydropyrimidine dehydrogenase | 0.4 |
| TTN | titin | 0.39 |
| DUSP14 | dual specificity phosphatase 14 | 0.38 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.37 |
| WTIP | Wilms tumor 1 interacting protein | 0.36 |
| ZNF397 | zinc finger protein 397 | 0.36 |
| C6ORF47 | chromosome 6 open reading frame 47 | 0.35 |
| THAP3 | THAP domain containing, apoptosis associated protein 3 | 0.34 |
| TRIM62 | tripartite motif containing 62 | 0.34 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | 0.34 |
| NFIB | nuclear factor I/B | 0.33 |
| PET117 | PET117 homolog (S. cerevisiae) | 0.33 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.33 |
| HHEX | hematopoietically expressed homeobox | 0.33 |
| SVBP | small vasohibin binding protein | 0.33 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | 0.32 |
| TYSND1 | trypsin domain containing 1 | 0.32 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | 0.31 |
| TMEM64 | transmembrane protein 64 | 0.31 |
| CCDC9B | coiled-coil domain containing 9B | 0.31 |
| RNF130 | ring finger protein 130 | 0.3 |
| H3C1 | H3 clustered histone 1 | 0.3 |
| PLXNB1 | plexin B1 | 0.3 |
| PHF13 | PHD finger protein 13 | 0.3 |
| TMLHE | trimethyllysine hydroxylase, epsilon | 0.29 |
| DCUN1D1 | DCN1, defective in cullin neddylation 1, domain containing 1 | 0.29 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | 0.29 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.28 |
| NKAPD1 | NKAP domain containing 1 | 0.28 |
| SPHK2 | sphingosine kinase 2 | 0.28 |
| ZMAT5 | zinc finger, matrin-type 5 | 0.27 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | 0.27 |
| ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | 0.27 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.27 |
| ATXN1 | ataxin 1 | 0.27 |
| PACS2 | phosphofurin acidic cluster sorting protein 2 | 0.27 |
| RNF181 | ring finger protein 181 | 0.27 |
| FAM117B | family with sequence similarity 117, member B | 0.27 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | 0.27 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.26 |
| PXDN | peroxidasin | 0.26 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.26 |
| ANKRD36 | ankyrin repeat domain 36 | 0.26 |
| FBH1 | F-box DNA helicase 1 | 0.25 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | 0.25 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.25 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.25 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.25 |
| SLC41A1 | solute carrier family 41 (magnesium transporter), member 1 | 0.25 |
| ZNF805 | zinc finger protein 805 | 0.25 |
| FAT4 | FAT atypical cadherin 4 | 0.24 |
| CMIP | c-Maf inducing protein | 0.24 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.24 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.24 |
| CFAP410 | cilia and flagella associated protein 410 | 0.24 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.24 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.24 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 0.23 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.23 |
| ATL1 | atlastin GTPase 1 | 0.23 |
| BAIAP2 | BAI1-associated protein 2 | 0.23 |
| ZFP62 | ZFP62 zinc finger protein | 0.22 |
| ZNF367 | zinc finger protein 367 | 0.22 |
| ZWINT | ZW10 interacting kinetochore protein | 0.22 |
| MLF1 | myeloid leukemia factor 1 | 0.22 |
| WASF3 | WAS protein family, member 3 | 0.22 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.22 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | 0.22 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | 0.22 |
| C1ORF112 | chromosome 1 open reading frame 112 | 0.22 |
| MKRN1 | makorin ring finger protein 1 | 0.22 |
| HBA1 | hemoglobin, alpha 1 | 0.22 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.21 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.21 |
| PRRX2 | paired related homeobox 2 | 0.21 |
| GPANK1 | G patch domain and ankyrin repeats 1 | 0.21 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.21 |
| MPC2 | mitochondrial pyruvate carrier 2 | 0.21 |
| LIPT2 | lipoyl(octanoyl) transferase 2 (putative) | 0.21 |
| FOXO1 | forkhead box O1 | 0.21 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 0.21 |
| ANTXR1 | anthrax toxin receptor 1 | 0.21 |
| MYO15A | myosin XVA | 0.21 |
| BDNF | brain-derived neurotrophic factor | 0.21 |
| FBXW2 | F-box and WD repeat domain containing 2 | 0.21 |
| ABITRAM | actin binding transcription modulator | 0.2 |
| H1-2 | H1.2 linker histone, cluster member | 0.2 |
| RNF111 | ring finger protein 111 | 0.2 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | 0.2 |
| FRRS1 | ferric-chelate reductase 1 | 0.2 |
| C1ORF52 | chromosome 1 open reading frame 52 | 0.2 |
| KDM4D | lysine (K)-specific demethylase 4D | 0.2 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MPHOSPH9 | M-phase phosphoprotein 9 | -0.81 |
| ZBTB49 | zinc finger and BTB domain containing 49 | -0.8 |
| THAP9 | THAP domain containing 9 | -0.79 |
| TRIM29 | tripartite motif containing 29 | -0.78 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.76 |
| ZNF469 | zinc finger protein 469 | -0.74 |
| NRM | nurim (nuclear envelope membrane protein) | -0.71 |
| MFSD14B | major facilitator superfamily domain containing 14B | -0.71 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | -0.65 |
| SARDH | sarcosine dehydrogenase | -0.64 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.63 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.62 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.62 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | -0.61 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | -0.57 |
| NLGN2 | neuroligin 2 | -0.55 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.53 |
| SMO | smoothened, frizzled class receptor | -0.52 |
| ZNF823 | zinc finger protein 823 | -0.51 |
| TMEM179B | transmembrane protein 179B | -0.51 |
| SYTL1 | synaptotagmin-like 1 | -0.51 |
| HMCN1 | hemicentin 1 | -0.5 |
| ITPRIPL1 | inositol 1,4,5-trisphosphate receptor interacting protein-like 1 | -0.49 |
| APOBEC3F | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F | -0.48 |
| PSEN1 | presenilin 1 | -0.48 |
| PLAUR | plasminogen activator, urokinase receptor | -0.47 |
| SETD9 | SET domain containing 9 | -0.45 |
| PLSCR3 | phospholipid scramblase 3 | -0.45 |
| TEC | tec protein tyrosine kinase | -0.44 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -0.43 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.43 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.43 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -0.42 |
| TMEM260 | transmembrane protein 260 | -0.4 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.39 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.39 |
| MYH4 | myosin, heavy chain 4, skeletal muscle | -0.38 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.37 |
| C2CD3 | C2 calcium-dependent domain containing 3 | -0.37 |
| MOSPD3 | motile sperm domain containing 3 | -0.37 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | -0.37 |
| SGCE | sarcoglycan, epsilon | -0.36 |
| METTL25 | methyltransferase like 25 | -0.36 |
| GM2A | GM2 ganglioside activator | -0.36 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.36 |
| DEAF1 | DEAF1 transcription factor | -0.36 |
| SLC35F3 | solute carrier family 35, member F3 | -0.35 |
| ZNF761 | zinc finger protein 761 | -0.35 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | -0.35 |
| CD99 | CD99 molecule | -0.35 |
| MEX3A | mex-3 RNA binding family member A | -0.34 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.34 |
| RNF220 | ring finger protein 220 | -0.34 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.33 |
| ATP9B | ATPase, class II, type 9B | -0.33 |
| RAB27B | RAB27B, member RAS oncogene family | -0.33 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.33 |
| TXNDC11 | thioredoxin domain containing 11 | -0.33 |
| LIME1 | Lck interacting transmembrane adaptor 1 | -0.32 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -0.32 |
| LPIN2 | lipin 2 | -0.32 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | -0.31 |
| PITPNM1 | phosphatidylinositol transfer protein, membrane-associated 1 | -0.31 |
| METTL26 | methyltransferase like 26 | -0.31 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | -0.31 |
| WNT10B | wingless-type MMTV integration site family, member 10B | -0.31 |
| NIN | ninein (GSK3B interacting protein) | -0.31 |
| HLA-F | major histocompatibility complex, class I, F | -0.3 |
| ORMDL1 | ORMDL sphingolipid biosynthesis regulator 1 | -0.3 |
| LRRC28 | leucine rich repeat containing 28 | -0.3 |
| RARA | retinoic acid receptor, alpha | -0.3 |
| ZNF655 | zinc finger protein 655 | -0.3 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | -0.3 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.3 |
| LYSMD2 | LysM, putative peptidoglycan-binding, domain containing 2 | -0.29 |
| MTFR1L | mitochondrial fission regulator 1-like | -0.29 |
| YIPF4 | Yip1 domain family, member 4 | -0.29 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | -0.29 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.29 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | -0.28 |
| RPE | ribulose-5-phosphate-3-epimerase | -0.28 |
| ATM | ATM serine/threonine kinase | -0.28 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.27 |
| TMEM246 | transmembrane protein 246 | -0.27 |
| PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | -0.27 |
| ZNF564 | zinc finger protein 564 | -0.27 |
| NEU3 | sialidase 3 (membrane sialidase) | -0.27 |
| ENTR1 | endosome associated trafficking regulator 1 | -0.27 |
| ANKRD12 | ankyrin repeat domain 12 | -0.27 |
| TSKU | tsukushi, small leucine rich proteoglycan | -0.27 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.27 |
| SLX4 | SLX4 structure-specific endonuclease subunit | -0.26 |
| LGALSL | lectin, galactoside-binding-like | -0.26 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.26 |
| PARD6A | par-6 family cell polarity regulator alpha | -0.26 |
| ANKRD22 | ankyrin repeat domain 22 | -0.26 |
| CALU | calumenin | -0.25 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.25 |
| ATXN1L | ataxin 1-like | -0.25 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.25 |
