abnormal adenohypophysis development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant formation or incomplete differentiation of the anterior lobe of the pituitary gland which arises as a pouch-like outgrowth of ectoderm known as the hypophyseal (Rathke's) pouch from the dorsal midline roof of the stomodeum (primitive oral cavity); the hypophyseal pouch grows toward the brain and the neurohypophyseal bud; as the hypophyseal pouch and the infundibulum make contact, the hypophyseal pouch loses its connection with the pharynx, creating a hollow ball of cells that lies inferior to the floor of the diencephalon posterior to the optic chiasm; these cells undergo division, the central chamber gradually disappears, and this endocrine mass becomes the anterior pituitary gland; the fully developed adenohypophysis consists of a glandular pars distalis, a thin proximal extension called the pars tuberalis, and a narrow pars intermedia (Mammalian Phenotype Ontology, MP_0013337)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0013337
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22 gene mutations causing the abnormal adenohypophysis development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AES amino-terminal enhancer of split
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BMP4 bone morphogenetic protein 4
CHD7 chromodomain helicase DNA binding protein 7
FGF10 fibroblast growth factor 10
FGFR2 fibroblast growth factor receptor 2
FOXC1 forkhead box C1
FUZ fuzzy planar cell polarity protein
HESX1 HESX homeobox 1
HHEX hematopoietically expressed homeobox
ISL1 ISL LIM homeobox 1
LHX3 LIM homeobox 3
LHX4 LIM homeobox 4
NKX2-1 NK2 homeobox 1
NOG noggin
PGAP1 post-GPI attachment to proteins 1
PITX2 paired-like homeodomain 2
PROP1 PROP paired-like homeobox 1
SOX2 SRY (sex determining region Y)-box 2
SOX3 SRY (sex determining region Y)-box 3
TCOF1 Treacher Collins-Franceschetti syndrome 1