abnormal aldosterone level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule (Mammalian Phenotype Ontology, MP_0011415)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011415
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Genes

35 gene mutations causing the abnormal aldosterone level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR2 angiotensin II receptor, type 2
BSND barttin CLCNK-type chloride channel accessory beta subunit
CLDN7 claudin 7
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KCNK3 potassium channel, two pore domain subfamily K, member 3
LOC102723475 putative uncharacterized protein LOC388820
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPR1 natriuretic peptide receptor 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
POMC proopiomelanocortin
REN renin
SCNN1B sodium channel, non voltage gated 1 beta subunit
SGK1 serum/glucocorticoid regulated kinase 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
STAR steroidogenic acute regulatory protein
STK39 serine threonine kinase 39
TGFB1 transforming growth factor, beta 1
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WNK4 WNK lysine deficient protein kinase 4
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