abnormal axon guidance Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues (Mammalian Phenotype Ontology, MP_0002961)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002961
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Genes

40 gene mutations causing the abnormal axon guidance phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BHLHE22 basic helix-loop-helix family, member e22
BMPR1B bone morphogenetic protein receptor, type IB
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CNTN1 contactin 1
DCC DCC netrin 1 receptor
DCLK1 doublecortin-like kinase 1
EFNB2 ephrin-B2
EN1 engrailed homeobox 1
ENAH enabled homolog (Drosophila)
EPHA4 EPH receptor A4
EPHA8 EPH receptor A8
EPHB2 EPH receptor B2
FEZF2 FEZ family zinc finger 2
GAP43 growth associated protein 43
GATA3 GATA binding protein 3
HOXB1 homeobox B1
ISPD isoprenoid synthase domain containing
KLF7 Kruppel-like factor 7 (ubiquitous)
L1CAM L1 cell adhesion molecule
LHX5 LIM homeobox 5
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MNX1 motor neuron and pancreas homeobox 1
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NGFR nerve growth factor receptor
NKX2-8 NK2 homeobox 8
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRP1 neuropilin 1
NRP2 neuropilin 2
PLXNA3 plexin A3
PLXNA4 plexin A4
PRDM8 PR domain containing 8
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SOX10 SRY (sex determining region Y)-box 10
TUBB3 tubulin, beta 3 class III
VAX1 ventral anterior homeobox 1
VAX2 ventral anterior homeobox 2