abnormal brown fat cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria (Mammalian Phenotype Ontology, MP_0009116)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009116
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30 gene mutations causing the abnormal brown fat cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ARID5B AT rich interactive domain 5B (MRF1-like)
ARRDC3 arrestin domain containing 3
CAV1 caveolin 1, caveolae protein, 22kDa
CERS6 ceramide synthase 6
CNOT3 CCR4-NOT transcription complex, subunit 3
CRHR2 corticotropin releasing hormone receptor 2
CRTC3 CREB regulated transcription coactivator 3
FGF21 fibroblast growth factor 21
FGL1 fibrinogen-like 1
GNAS GNAS complex locus
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
KL klotho
LCLAT1 lysocardiolipin acyltransferase 1
LEP leptin
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LRP6 low density lipoprotein receptor-related protein 6
MARK4 MAP/microtubule affinity-regulating kinase 4
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC3R melanocortin 3 receptor
MOGAT2 monoacylglycerol O-acyltransferase 2
NCOA3 nuclear receptor coactivator 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLIN1 perilipin 1
PPARG peroxisome proliferator-activated receptor gamma
PRKG1 protein kinase, cGMP-dependent, type I
SERTAD2 SERTA domain containing 2
SRA1 steroid receptor RNA activator 1
TWIST2 twist family bHLH transcription factor 2