abnormal cellular replicative senescence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division (Mammalian Phenotype Ontology, MP_0008007)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008007
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55 gene mutations causing the abnormal cellular replicative senescence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ATMIN ATM interactor
ATR ATR serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDC14B cell division cycle 14B
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CKS1B CDC28 protein kinase regulatory subunit 1B
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
COMMD3-BMI1 COMMD3-BMI1 readthrough
CTC1 CTS telomere maintenance complex component 1
CUL7 cullin 7
DICER1 dicer 1, ribonuclease type III
EP300 E1A binding protein p300
ERCC1 excision repair cross-complementation group 1
EWSR1 EWS RNA-binding protein 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ING1 inhibitor of growth family, member 1
KDM5A lysine (K)-specific demethylase 5A
KMT2A lysine (K)-specific methyltransferase 2A
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCM9 minichromosome maintenance complex component 9
MTF2 metal response element binding transcription factor 2
NINJ1 ninjurin 1
NONO non-POU domain containing, octamer-binding
PA2G4 proliferation-associated 2G4, 38kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PHC2 polyhomeotic homolog 2 (Drosophila)
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRMT6 protein arginine methyltransferase 6
RAD9B RAD9 homolog B (S. pombe)
RTEL1 regulator of telomere elongation helicase 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SIRT2 sirtuin 2
SIRT6 sirtuin 6
SKIL SKI-like proto-oncogene
SLX4 SLX4 structure-specific endonuclease subunit
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERT telomerase reverse transcriptase
TP53 tumor protein p53
TP63 tumor protein p63
TPP2 tripeptidyl peptidase II
TRIM27 tripartite motif containing 27
UBC ubiquitin C
UIMC1 ubiquitin interaction motif containing 1
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
ZNF277 zinc finger protein 277