abnormal circulating renin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I (Mammalian Phenotype Ontology, MP_0003349)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003349
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Genes

24 gene mutations causing the abnormal circulating renin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
ELN elastin
GJA5 gap junction protein, alpha 5, 40kDa
LOC102723475 putative uncharacterized protein LOC388820
MYH11 myosin, heavy chain 11, smooth muscle
NCF1 neutrophil cytosolic factor 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPR1 natriuretic peptide receptor 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
REN renin
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SUCNR1 succinate receptor 1
TGFB1 transforming growth factor, beta 1
VAMP8 vesicle-associated membrane protein 8
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNK4 WNK lysine deficient protein kinase 4
Funding