abnormal cochlear outer hair cell electromotility Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomalous motility of the cochlear OHCs in response to electrical stimulation; normally, the motile response (i.e. rapid change in length and stiffness of OHCs) is closely coupled to the changing transduction current and provides a region-specific amplification in the movement of the spiral organ that enhances transduction at the IHCs in that specific region of the cochlear spiral, increasing both sensitivity and specificity; electromotility is believed to arise through voltage-gated conformational changes in motor protein (prestin) or proteins located in the lateral wall of the OHC (Mammalian Phenotype Ontology, MP_0004435)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004435
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2 gene mutations causing the abnormal cochlear outer hair cell electromotility phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
SLC26A5 solute carrier family 26 (anion exchanger), member 5
THRB thyroid hormone receptor, beta