abnormal developmental vascular remodeling Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the process by which existing vessels are reorganized during development (Mammalian Phenotype Ontology, MP_0009577)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009577
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Genes

40 gene mutations causing the abnormal developmental vascular remodeling phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVRL1 activin A receptor type II-like 1
AHR aryl hydrocarbon receptor
AIP aryl hydrocarbon receptor interacting protein
ANGPT2 angiopoietin 2
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ATE1 arginyltransferase 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CCM2 cerebral cavernous malformation 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DLL4 delta-like 4 (Drosophila)
EDNRA endothelin receptor type A
EFNB2 ephrin-B2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FLNA filamin A, alpha
FOXC1 forkhead box C1
GPC3 glypican 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
LEF1 lymphoid enhancer-binding factor 1
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MIB1 mindbomb E3 ubiquitin protein ligase 1
MYH11 myosin, heavy chain 11, smooth muscle
NRARP NOTCH-regulated ankyrin repeat protein
NUMB numb homolog (Drosophila)
PCSK5 proprotein convertase subtilisin/kexin type 5
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRB protein tyrosine phosphatase, receptor type, B
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RIPPLY3 ripply transcriptional repressor 3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
TBX4 T-box 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM100 transmembrane protein 100
VEGFA vascular endothelial growth factor A
Funding