abnormal dopamine level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater or less than the normal amount of this catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary (Mammalian Phenotype Ontology, MP_0001905)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001905
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68 gene mutations causing the abnormal dopamine level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRL3 adhesion G protein-coupled receptor L3
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
AQP4 aquaporin 4
CD81 CD81 molecule
CHRM1 cholinergic receptor, muscarinic 1
CHRM5 cholinergic receptor, muscarinic 5
CNTNAP4 contactin associated protein-like 4
COMT catechol-O-methyltransferase
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EN1 engrailed homeobox 1
ESR2 estrogen receptor 2 (ER beta)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXP2 forkhead box P2
FYN FYN proto-oncogene, Src family tyrosine kinase
GJB6 gap junction protein, beta 6, 30kDa
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRM2 glutamate receptor, metabotropic 2
GSTM5 glutathione S-transferase mu 5
HIPK2 homeodomain interacting protein kinase 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
IL6 interleukin 6
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
LPAR1 lysophosphatidic acid receptor 1
MAOA monoamine oxidase A
MAPK10 mitogen-activated protein kinase 10
MDK midkine (neurite growth-promoting factor 2)
NENF neudesin neurotrophic factor
NOS3 nitric oxide synthase 3 (endothelial cell)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTSR1 neurotensin receptor 1 (high affinity)
OPRL1 opiate receptor-like 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PINK1 PTEN induced putative kinase 1
PITX3 paired-like homeodomain 3
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PNKD paroxysmal nonkinesigenic dyskinesia
POMC proopiomelanocortin
PRL prolactin
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTS 6-pyruvoyltetrahydropterin synthase
RNLS renalase, FAD-dependent amine oxidase
SH3KBP1 SH3-domain kinase binding protein 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SSTR2 somatostatin receptor 2
TAAR1 trace amine associated receptor 1
TACR1 tachykinin receptor 1
TGFB2 transforming growth factor, beta 2
TH tyrosine hydroxylase
TNC tenascin C
TOR1A torsin family 1, member A (torsin A)
UBE3A ubiquitin protein ligase E3A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor