abnormal endoderm development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any abnormality in the formation of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) during gastrulation; endoderm gives rise to the epithelial lining of the gastrointestinal and respiratory tracts; the parenchyma of the tonsils, the liver, the thymus, the thyroid, the parathyroids, and the pancreas; the epithelial lining of the urinary bladder, urethra, and prostate; and the epithelial lining of the tympanic cavity, tympanic antrum, and auditory tube (Mammalian Phenotype Ontology, MP_0001685)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001685
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46 gene mutations causing the abnormal endoderm development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APC adenomatous polyposis coli
ATAD3A ATPase family, AAA domain containing 3A
BPTF bromodomain PHD finger transcription factor
COL2A1 collagen, type II, alpha 1
CRB2 crumbs family member 2
CUBN cubilin (intrinsic factor-cobalamin receptor)
DACT1 dishevelled-binding antagonist of beta-catenin 1
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DSP desmoplakin
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FGFR2 fibroblast growth factor receptor 2
FLCN folliculin
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXA2 forkhead box A2
FOXH1 forkhead box H1
GATA6 GATA binding protein 6
GDF3 growth differentiation factor 3
GRB2 growth factor receptor-bound protein 2
HIRA histone cell cycle regulator
HSBP1 heat shock factor binding protein 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFT172 intraflagellar transport 172
MAX MYC associated factor X
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
NCKAP1 NCK-associated protein 1
NODAL nodal growth differentiation factor
NSD1 nuclear receptor binding SET domain protein 1
OTX2 orthodenticle homeobox 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
SALL4 spalt-like transcription factor 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC31A1 solute carrier family 31 (copper transporter), member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SOX17 SRY (sex determining region Y)-box 17
TDGF1 teratocarcinoma-derived growth factor 1
TPT1 tumor protein, translationally-controlled 1
TRIM28 tripartite motif containing 28
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WLS wntless Wnt ligand secretion mediator
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZIC3 Zic family member 3