abnormal foam cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of a cell with a vacuolated appearance due to abnormal deposition and retention of lipoproteins, and typically seen in atherolosclerotic lesions, as well as other conditions, and derived from or related to the group of cells having the ability to take up and sequester inert particles and vital dyes, including macrophages and macrophage precursors, specialized endothelial cells lining the sinusoids of the liver, spleen, and bone marrow, and macrophages of lymphatic tissue and fibroblasts of bone marrow (Mammalian Phenotype Ontology, MP_0009840)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009840
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8 gene mutations causing the abnormal foam cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRF5 adhesion G protein-coupled receptor F5
IDUA iduronidase, alpha-L-
LDLR low density lipoprotein receptor
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
NPC1 Niemann-Pick disease, type C1
PLA2G15 phospholipase A2, group XV
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal