abnormal germinal center b cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes (Mammalian Phenotype Ontology, MP_0008192)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008192
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7 gene mutations causing the abnormal germinal center b cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL6 B-cell CLL/lymphoma 6
CD28 CD28 molecule
CR2 complement component (3d/Epstein Barr virus) receptor 2
IL21 interleukin 21
MIR155 microRNA 155
PKN1 protein kinase N1
SH2D1A SH2 domain containing 1A