abnormal hematopoietic stem cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages (Mammalian Phenotype Ontology, MP_0010763)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010763
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21 gene mutations causing the abnormal hematopoietic stem cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ASXL1 additional sex combs like transcriptional regulator 1
BID BH3 interacting domain death agonist
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
FANCC Fanconi anemia, complementation group C
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
JAM2 junctional adhesion molecule 2
KIAA0101 KIAA0101
KMT2A lysine (K)-specific methyltransferase 2A
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MECOM MDS1 and EVI1 complex locus
MSI2 musashi RNA-binding protein 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PER2 period circadian clock 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RPL27A ribosomal protein L27a
SPI1 Spi-1 proto-oncogene
TET2 tet methylcytosine dioxygenase 2
TP53 tumor protein p53