any structural abnormality of the cuboidal epithelial cells found in the collecting ducts of the kidney which regulate sodium and potassium balance via channels located on the cells apical membrane. Aldosterone increases the number of Na+/K+-ATPase pumps that allow increased sodium reabsorption and potassium secretion whereas antidiuretic hormone (vasopressin) determines the expression of aquaporin channels on the cell surface; together, aldosterone and vasopressin let the principal cell control the quantity of water that is reabsorbed (Mammalian Phenotype Ontology, MP_0011757)
1 gene mutations causing the abnormal kidney collecting duct principal cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.
