abnormal langerhans cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus (Mammalian Phenotype Ontology, MP_0008117)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008117
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10 gene mutations causing the abnormal langerhans cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHR aryl hydrocarbon receptor
CD207 CD207 molecule, langerin
CLEC10A C-type lectin domain family 10, member A
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
IL34 interleukin 34
ITGB6 integrin, beta 6
RUNX3 runt-related transcription factor 3
TGFB1 transforming growth factor, beta 1
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11