abnormal level of surface class ii molecules Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface (Mammalian Phenotype Ontology, MP_0005042)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005042
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Genes

20 gene mutations causing the abnormal level of surface class ii molecules phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CIITA class II, major histocompatibility complex, transactivator
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFNG interferon, gamma
IL10 interleukin 10
IL2 interleukin 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
NUP98 nucleoporin 98kDa
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAG1 recombination activating gene 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR4 toll-like receptor 4
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