abnormal natural killer cell mediated cytotoxicity Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the process of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors (Mammalian Phenotype Ontology, MP_0011719)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011719
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59 gene mutations causing the abnormal natural killer cell mediated cytotoxicity phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CD226 CD226 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD247 CD247 molecule
CD44 CD44 molecule (Indian blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLNK cytokine-dependent hematopoietic cell linker
DTNBP1 dystrobrevin binding protein 1
ELF4 E74-like factor 4 (ets domain transcription factor)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FOXQ1 forkhead box Q1
GFI1 growth factor independent 1 transcription repressor
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCST hematopoietic cell signal transducer
HLA-G major histocompatibility complex, class I, G
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IL12A interleukin 12A
IL12B interleukin 12B
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL2 interleukin 2
IL21R interleukin 21 receptor
IL2RG interleukin 2 receptor, gamma
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF1 interferon regulatory factor 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LYST lysosomal trafficking regulator
MAP3K8 mitogen-activated protein kinase kinase kinase 8
NCR1 natural cytotoxicity triggering receptor 1
NFIL3 nuclear factor, interleukin 3 regulated
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAB27A RAB27A, member RAS oncogene family
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RHBDD3 rhomboid domain containing 3
RNF19B ring finger protein 19B
SH2D1A SH2 domain containing 1A
SH2D1B SH2 domain containing 1B
SLAMF7 SLAM family member 7
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STX11 syntaxin 11
TBX21 T-box 21
TICAM1 toll-like receptor adaptor molecule 1
TLR9 toll-like receptor 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TYROBP TYRO protein tyrosine kinase binding protein
VAV1 vav 1 guanine nucleotide exchange factor