abnormal pancreatic alpha cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the cells of the pancreas that secrete glucagon (Mammalian Phenotype Ontology, MP_0005216)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005216
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37 gene mutations causing the abnormal pancreatic alpha cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AQP7 aquaporin 7
ARX aristaless related homeobox
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
DACH1 dachshund family transcription factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
G6PC3 glucose 6 phosphatase, catalytic, 3
GCG glucagon
GCGR glucagon receptor
GDF11 growth differentiation factor 11
GLIS3 GLIS family zinc finger 3
HADH hydroxyacyl-CoA dehydrogenase
IL6 interleukin 6
INS insulin
INSM1 insulinoma-associated 1
ISL1 ISL LIM homeobox 1
LEPR leptin receptor
MIR375 microRNA 375
NEUROD1 neuronal differentiation 1
NEUROG3 neurogenin 3
NKX2-2 NK2 homeobox 2
ONECUT1 one cut homeobox 1
PAX6 paired box 6
PCSK2 proprotein convertase subtilisin/kexin type 2
PDX1 pancreatic and duodenal homeobox 1
PTF1A pancreas specific transcription factor, 1a
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RIMS2 regulating synaptic membrane exocytosis 2
RIPPLY3 ripply transcriptional repressor 3
SEC23B Sec23 homolog B (S. cerevisiae)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SOX9 SRY (sex determining region Y)-box 9
SSTR5 somatostatin receptor 5
TLE3 transducin-like enhancer of split 3