abnormal regulatory T cell physiology Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function (Mammalian Phenotype Ontology, MP_0004946)
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Genes

25 gene mutations causing the abnormal regulatory T cell physiology phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADGRE1 adhesion G protein-coupled receptor E1
AIRE autoimmune regulator
CCL1 chemokine (C-C motif) ligand 1
CD247 CD247 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DTX1 deltex 1, E3 ubiquitin ligase
FGL2 fibrinogen-like 2
FOXP3 forkhead box P3
GPR15 G protein-coupled receptor 15
GPR174 G protein-coupled receptor 174
IDO2 indoleamine 2,3-dioxygenase 2
IL10 interleukin 10
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL9R interleukin 9 receptor
MIR125A microRNA 125a
MIR146A microRNA 146a
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RXRA retinoid X receptor, alpha
SELL selectin L
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa