abnormal regulatory t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity (Mammalian Phenotype Ontology, MP_0004972)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004972
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Genes

54 gene mutations causing the abnormal regulatory t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
ARL4D ADP-ribosylation factor-like 4D
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CARD11 caspase recruitment domain family, member 11
CD1D CD1d molecule
CD247 CD247 molecule
CD27 CD27 molecule
CD28 CD28 molecule
CD40LG CD40 ligand
CD5 CD5 molecule
CD70 CD70 molecule
CD86 CD86 molecule
CTSV cathepsin V
E2F1 E2F transcription factor 1
FADS1 fatty acid desaturase 1
FOXP3 forkhead box P3
GPR15 G protein-coupled receptor 15
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL15 interleukin 15
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
KRAS Kirsten rat sarcoma viral oncogene homolog
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LGALS9B lectin, galactoside-binding, soluble, 9B
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MIR155 microRNA 155
NCKAP1L NCK-associated protein 1-like
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDCD1 programmed cell death 1
PEX3 peroxisomal biogenesis factor 3
PI16 peptidase inhibitor 16
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
SELL selectin L
SETD5 SET domain containing 5
SGOL1 shugoshin-like 1 (S. pombe)
SYTL1 synaptotagmin-like 1
TESPA1 thymocyte expressed, positive selection associated 1
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THEMIS thymocyte selection associated
TXNIP thioredoxin interacting protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR37 WD repeat domain 37
XCL1 chemokine (C motif) ligand 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF335 zinc finger protein 335