abnormal sclerotome morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord; normally, sclerotomal cells from adjacent somites become merged in intersomitically located masses that are the primordia of the centra of the vertebrae (Mammalian Phenotype Ontology, MP_0006029)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006029
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18 gene mutations causing the abnormal sclerotome morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APH1A APH1A gamma secretase subunit
DISP1 dispatched homolog 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
DMRT2 doublesex and mab-3 related transcription factor 2
EPHA2 EPH receptor A2
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MDFI MyoD family inhibitor
MECOM MDS1 and EVI1 complex locus
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
NKX3-2 NK3 homeobox 2
NOTO notochord homeobox
PAX1 paired box 1
PSEN1 presenilin 1
SCX scleraxis basic helix-loop-helix transcription factor
SMAD5 SMAD family member 5
TCF15 transcription factor 15 (basic helix-loop-helix)
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UNCX UNC homeobox