abnormal sensitivity to induced morbidity/mortality Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the amount of an external agent required to cause death or diseased state (Mammalian Phenotype Ontology, MP_0020148)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0020148
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Genes

358 gene mutations causing the abnormal sensitivity to induced morbidity/mortality phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
A4GALT alpha 1,4-galactosyltransferase
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACADVL acyl-CoA dehydrogenase, very long chain
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACHE acetylcholinesterase (Yt blood group)
ADAM17 ADAM metallopeptidase domain 17
ADGRV1 adhesion G protein-coupled receptor V1
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA2B adenosine A2b receptor
AGTR2 angiotensin II receptor, type 2
AHR aryl hydrocarbon receptor
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
AMACR alpha-methylacyl-CoA racemase
ANGPTL4 angiopoietin-like 4
ANK1 ankyrin 1, erythrocytic
ANXA1 annexin A1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AQP4 aquaporin 4
ARX aristaless related homeobox
ASGR1 asialoglycoprotein receptor 1
ASGR2 asialoglycoprotein receptor 2
ATF6 activating transcription factor 6
ATM ATM serine/threonine kinase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BCHE butyrylcholinesterase
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BDKRB2 bradykinin receptor B2
BID BH3 interacting domain death agonist
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C3 complement component 3
C3AR1 complement component 3a receptor 1
C4A complement component 4A (Rodgers blood group)
C5AR1 complement component 5a receptor 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CASP4 caspase 4, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CCM2L cerebral cavernous malformation 2-like
CCNG1 cyclin G1
CD19 CD19 molecule
CD226 CD226 molecule
CD300A CD300a molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CERK ceramide kinase
CFP complement factor properdin
CHEK2 checkpoint kinase 2
CLCN3 chloride channel, voltage-sensitive 3
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC4M C-type lectin domain family 4, member M
CLEC7A C-type lectin domain family 7, member A
CLIC4 chloride intracellular channel 4
CNR1 cannabinoid receptor 1 (brain)
COPS6 COP9 signalosome subunit 6
CPA3 carboxypeptidase A3 (mast cell)
CPB2 carboxypeptidase B2 (plasma)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CREB3L3 cAMP responsive element binding protein 3-like 3
CRLF2 cytokine receptor-like factor 2
CTH cystathionine gamma-lyase
CTNNA3 catenin (cadherin-associated protein), alpha 3
CUZD1 CUB and zona pellucida-like domains 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DNASE1 deoxyribonuclease I
DOCK2 dedicator of cytokinesis 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DUSP1 dual specificity phosphatase 1
EDN2 endothelin 2
EEF2 eukaryotic translation elongation factor 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERCC1 excision repair cross-complementation group 1
ESR2 estrogen receptor 2 (ER beta)
EWSR1 EWS RNA-binding protein 1
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FABP3 fatty acid binding protein 3, muscle and heart
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAIM Fas apoptotic inhibitory molecule
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCMR Fc fragment of IgM receptor
FFAR2 free fatty acid receptor 2
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FUS FUS RNA binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PC3 glucose 6 phosphatase, catalytic, 3
GAS6 growth arrest-specific 6
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLP2R glucagon-like peptide 2 receptor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRM7 glutamate receptor, metabotropic 7
GSTA3 glutathione S-transferase alpha 3
GSTZ1 glutathione S-transferase zeta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2AFX H2A histone family, member X
HABP2 hyaluronan binding protein 2
HCST hematopoietic cell signal transducer
HGFAC HGF activator
HMGN1 high mobility group nucleosome binding domain 1
HMOX2 heme oxygenase 2
HP haptoglobin
HSPA1B heat shock 70kDa protein 1B
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HTT huntingtin
IFIH1 interferon induced with helicase C domain 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL1B interleukin 1, beta
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL27RA interleukin 27 receptor, alpha
IL33 interleukin 33
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ING1 inhibitor of growth family, member 1
ING4 inhibitor of growth family, member 4
INSR insulin receptor
IP6K2 inositol hexakisphosphate kinase 2
IRAK2 interleukin-1 receptor-associated kinase 2
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
IVNS1ABP influenza virus NS1A binding protein
JAM2 junctional adhesion molecule 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCP kielin/chordin-like protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLF15 Kruppel-like factor 15
KLK8 kallikrein-related peptidase 8
KMT2E lysine (K)-specific methyltransferase 2E
LAMA4 laminin, alpha 4
LASP1 LIM and SH3 protein 1
LAT2 linker for activation of T cells family, member 2
LCN2 lipocalin 2
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY75 lymphocyte antigen 75
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK9 mitogen-activated protein kinase 9
MARCO macrophage receptor with collagenous structure
MBOAT4 membrane bound O-acyltransferase domain containing 4
MBTPS1 membrane-bound transcription factor peptidase, site 1
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MECOM MDS1 and EVI1 complex locus
MERTK MER proto-oncogene, tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR144 microRNA 144
MIR451A microRNA 451a
MLXIPL MLX interacting protein-like
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MST1R macrophage stimulating 1 receptor
MUC2 mucin 2, oligomeric mucus/gel-forming
MUS81 MUS81 structure-specific endonuclease subunit
MX1 MX dynamin-like GTPase 1
MYLK3 myosin light chain kinase 3
NBN nibrin
NCF1 neutrophil cytosolic factor 1
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRP6 NLR family, pyrin domain containing 6
NOD2 nucleotide-binding oligomerization domain containing 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NPAS4 neuronal PAS domain protein 4
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRG1 neuregulin 1
NRP2 neuropilin 2
OPRM1 opioid receptor, mu 1
OTC ornithine carbamoyltransferase
PARG poly (ADP-ribose) glycohydrolase
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDE4B phosphodiesterase 4B, cAMP-specific
PELI1 pellino E3 ubiquitin protein ligase 1
PENK proenkephalin
PER2 period circadian clock 2
PEX7 peroxisomal biogenesis factor 7
PGAP3 post-GPI attachment to proteins 3
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCL1 phospholipase C-like 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLG plasminogen
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNPLA6 patatin-like phospholipase domain containing 6
PNPLA8 patatin-like phospholipase domain containing 8
POSTN periostin, osteoblast specific factor
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRF1 perforin 1 (pore forming protein)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROS1 protein S (alpha)
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PTCH1 patched 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALBP1 ralA binding protein 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RB1 retinoblastoma 1
REG1B regenerating islet-derived 1 beta
RETNLB resistin like beta
RGN regucalcin
RGS4 regulator of G-protein signaling 4
RHBDD3 rhomboid domain containing 3
RHCG Rh family, C glycoprotein
RIPK3 receptor-interacting serine-threonine kinase 3
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPL27A ribosomal protein L27a
RRAGA Ras-related GTP binding A
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
S1PR3 sphingosine-1-phosphate receptor 3
SCN5A sodium channel, voltage gated, type V alpha subunit
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIRT2 sirtuin 2
SKIL SKI-like proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLPI secretory leukocyte peptidase inhibitor
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNAI2 snail family zinc finger 2
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
SOD3 superoxide dismutase 3, extracellular
SOSTDC1 sclerostin domain containing 1
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
SRXN1 sulfiredoxin 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIP1 stress-induced phosphoprotein 1
TGM2 transglutaminase 2
THBD thrombomodulin
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNXB tenascin XB
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53INP1 tumor protein p53 inducible nuclear protein 1
TPMT thiopurine S-methyltransferase
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM27 tripartite motif containing 27
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSLP thymic stromal lymphopoietin
TXNIP thioredoxin interacting protein
UIMC1 ubiquitin interaction motif containing 1
USP1 ubiquitin specific peptidase 1
UTRN utrophin
VASN vasorin
VCL vinculin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
YIPF6 Yip1 domain family, member 6
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF148 zinc finger protein 148