abnormal sertoli cell phagocytosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description altered ability of the Sertoli cells to endocytose and degrade the apoptotic spermatogenic cells and residual bodies (shed cytoplasts) during the maturation phase of spermiogenesis; normally, greater than 50 per cent of differentiating spermatogenic cells undergo apoptosis before maturing into spermatozoa, and these cells are selectively and rapidly eliminated through phagocytosis by Sertoli cells (Mammalian Phenotype Ontology, MP_0009851)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009851
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4 gene mutations causing the abnormal sertoli cell phagocytosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
EHD1 EH-domain containing 1
ELMO1 engulfment and cell motility 1
KATNB1 katanin p80 (WD repeat containing) subunit B 1
MERTK MER proto-oncogene, tyrosine kinase