abnormal small intestinal villus morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold (Mammalian Phenotype Ontology, MP_0008108)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008108
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33 gene mutations causing the abnormal small intestinal villus morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ANGPT2 angiopoietin 2
BRCA1 breast cancer 1, early onset
CLDN15 claudin 15
CRB3 crumbs family member 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
E2F4 E2F transcription factor 4, p107/p130-binding
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7
EP300 E1A binding protein p300
EPCAM epithelial cell adhesion molecule
EZR ezrin
FOXL1 forkhead box L1
HR hair growth associated
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
KLF5 Kruppel-like factor 5 (intestinal)
LIPA lipase A, lysosomal acid, cholesterol esterase
MAN2C1 mannosidase, alpha, class 2C, member 1
MCM2 minichromosome maintenance complex component 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1A myosin IA
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
RAB8A RAB8A, member RAS oncogene family
RC3H1 ring finger and CCCH-type domains 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAV1 salvador family WW domain containing protein 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
TDP2 tyrosyl-DNA phosphodiesterase 2
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
THRA thyroid hormone receptor, alpha
TNS3 tensin 3
WASF1 WAS protein family, member 1