abnormal sperm mitochondrial sheath morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum (Mammalian Phenotype Ontology, MP_0009832)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009832
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Genes

20 gene mutations causing the abnormal sperm mitochondrial sheath morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGFG1 ArfGAP with FG repeats 1
AKAP4 A kinase (PRKA) anchor protein 4
CNOT7 CCR4-NOT transcription complex, subunit 7
DPY19L2 dpy-19-like 2 (C. elegans)
GOPC golgi-associated PDZ and coiled-coil motif containing
GPX4 glutathione peroxidase 4
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MNS1 meiosis-specific nuclear structural 1
NSUN7 NOP2/Sun domain family, member 7
ODF1 outer dense fiber of sperm tails 1
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RXRB retinoid X receptor, beta
SEPP1 selenoprotein P, plasma, 1
SEPT4 septin 4
SLC26A8 solute carrier family 26 (anion exchanger), member 8
SLIRP SRA stem-loop interacting RNA binding protein
TALDO1 transaldolase 1
TMF1 TATA element modulatory factor 1
VDAC3 voltage-dependent anion channel 3
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