abnormal sperm principal piece morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece (Mammalian Phenotype Ontology, MP_0009836)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009836
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10 gene mutations causing the abnormal sperm principal piece morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AKAP4 A kinase (PRKA) anchor protein 4
DPY19L2 dpy-19-like 2 (C. elegans)
ENO4 enolase family member 4
GPX4 glutathione peroxidase 4
MNS1 meiosis-specific nuclear structural 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
SEPT4 septin 4
SPAG6 sperm associated antigen 6
TEKT4 tektin 4