abnormal thymus corticomedullary boundary morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells (Mammalian Phenotype Ontology, MP_0009543)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009543
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14 gene mutations causing the abnormal thymus corticomedullary boundary morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CTSV cathepsin V
LAMA2 laminin, alpha 2
MAP3K14 mitogen-activated protein kinase kinase kinase 14
NCAPH2 non-SMC condensin II complex, subunit H2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PIP prolactin-induced protein
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RECQL4 RecQ protein-like 4
RUNX1 runt-related transcription factor 1
SOCS1 suppressor of cytokine signaling 1
ZMPSTE24 zinc metallopeptidase STE24