abnormal trunk neural crest cell migration Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the trunk neural crest which lies between the vagal and sacral neural crest; there are two major pathways taken by the migrating trunk NCCs: (1) one group of cells fated to become melanocytes (the melanin-forming pigment cells) migrates dorsolaterally into the ectoderm towards the ventral midline and colonizes the skin and hair follicles; (2) a second group of cells migrates ventrolaterally through the anterior portion of each sclerotome; the cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons, whereas those that continue more ventrally form the sympathetic ganglia, chromaffin cells of the adrenal medulla, Schwann (precursor) cells, and the nerve clusters surrounding the aorta (Mammalian Phenotype Ontology, MP_0013012)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0013012
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1 gene mutations causing the abnormal trunk neural crest cell migration phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
EFNB2 ephrin-B2