abnormal tumor necrosis factor level Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium (Mammalian Phenotype Ontology, MP_0008752)
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Genes

49 gene mutations causing the abnormal tumor necrosis factor level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
ADORA2B adenosine A2b receptor
AHR aryl hydrocarbon receptor
B2M beta-2-microglobulin
C3 complement component 3
CBS cystathionine-beta-synthase
CD14 CD14 molecule
CD47 CD47 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CPB2 carboxypeptidase B2 (plasma)
CREBBP CREB binding protein
CUX1 cut-like homeobox 1
EGR1 early growth response 1
ELF4 E74-like factor 4 (ets domain transcription factor)
GKN2 gastrokine 2
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTRA2 HtrA serine peptidase 2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL10 interleukin 10
IL18 interleukin 18
IL36G interleukin 36, gamma
LRRC25 leucine rich repeat containing 25
MAGED1 melanoma antigen family D1
MEP1A meprin A, alpha (PABA peptide hydrolase)
MERTK MER proto-oncogene, tyrosine kinase
MYD88 myeloid differentiation primary response 88
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFR nerve growth factor receptor
NOD2 nucleotide-binding oligomerization domain containing 2
PDE4D phosphodiesterase 4D, cAMP-specific
PGLYRP2 peptidoglycan recognition protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RUNX3 runt-related transcription factor 3
SECTM1 secreted and transmembrane 1
SORT1 sortilin 1
SPON2 spondin 2, extracellular matrix protein
TBC1D23 TBC1 domain family, member 23
TBX21 T-box 21
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TREM2 triggering receptor expressed on myeloid cells 2
TRIM21 tripartite motif containing 21
TWIST2 twist family bHLH transcription factor 2
UNC93B1 unc-93 homolog B1 (C. elegans)
UVRAG UV radiation resistance associated
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZDHHC2 zinc finger, DHHC-type containing 2