| Dataset | MPO Gene-Phenotype Associations |
| Category | disease or phenotype associations |
| Type | phenotype |
| Description | any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor (Mammalian Phenotype Ontology, MP_0012727) |
| External Link | http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012727 |
| Similar Terms | |
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3 gene mutations causing the abnormal uterine spiral artery remodeling phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.
