abnormal uterine spiral artery remodeling Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor (Mammalian Phenotype Ontology, MP_0012727)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012727
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3 gene mutations causing the abnormal uterine spiral artery remodeling phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADM adrenomedullin
CALCRL calcitonin receptor-like
TYROBP TYRO protein tyrosine kinase binding protein