abnormal xenobiotic induced morbidity/mortality Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in induction of a diseased state or death caused by a foreign compound (Mammalian Phenotype Ontology, MP_0009765)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009765
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Genes

135 gene mutations causing the abnormal xenobiotic induced morbidity/mortality phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHR aryl hydrocarbon receptor
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANXA1 annexin A1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APOD apolipoprotein D
ATF6 activating transcription factor 6
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BCHE butyrylcholinesterase
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CASP4 caspase 4, apoptosis-related cysteine peptidase
CAT catalase
CCL13 chemokine (C-C motif) ligand 13
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC4M C-type lectin domain family 4, member M
CNR1 cannabinoid receptor 1 (brain)
CPA3 carboxypeptidase A3 (mast cell)
CREB3L3 cAMP responsive element binding protein 3-like 3
CRLF2 cytokine receptor-like factor 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DNASE1 deoxyribonuclease I
DOCK2 dedicator of cytokinesis 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DUSP1 dual specificity phosphatase 1
ERCC1 excision repair cross-complementation group 1
FADS1 fatty acid desaturase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAIM Fas apoptotic inhibitory molecule
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCMR Fc fragment of IgM receptor
FFAR2 free fatty acid receptor 2
FOXO3 forkhead box O3
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GCLM glutamate-cysteine ligase, modifier subunit
GLP2R glucagon-like peptide 2 receptor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRM7 glutamate receptor, metabotropic 7
GSTA3 glutathione S-transferase alpha 3
HGFAC HGF activator
HP haptoglobin
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HTT huntingtin
IFNG interferon, gamma
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL12A interleukin 12A
IL12B interleukin 12B
IL23A interleukin 23, alpha subunit p19
IL27RA interleukin 27 receptor, alpha
IL33 interleukin 33
IL6ST interleukin 6 signal transducer
ING4 inhibitor of growth family, member 4
INSR insulin receptor
IP6K2 inositol hexakisphosphate kinase 2
IRF1 interferon regulatory factor 1
IVNS1ABP influenza virus NS1A binding protein
JAM2 junctional adhesion molecule 2
KCNK2 potassium channel, two pore domain subfamily K, member 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK8 kallikrein-related peptidase 8
LAT2 linker for activation of T cells family, member 2
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBTPS1 membrane-bound transcription factor peptidase, site 1
MECOM MDS1 and EVI1 complex locus
MIR144 microRNA 144
MIR451A microRNA 451a
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
MUC2 mucin 2, oligomeric mucus/gel-forming
MUS81 MUS81 structure-specific endonuclease subunit
NFE2L2 nuclear factor, erythroid 2-like 2
NLRP6 NLR family, pyrin domain containing 6
NOD2 nucleotide-binding oligomerization domain containing 2
NPAS4 neuronal PAS domain protein 4
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NRG1 neuregulin 1
OPRM1 opioid receptor, mu 1
PARG poly (ADP-ribose) glycohydrolase
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PLCL1 phospholipase C-like 1
PNPLA6 patatin-like phospholipase domain containing 6
PPARG peroxisome proliferator-activated receptor gamma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RGS4 regulator of G-protein signaling 4
RHBDD3 rhomboid domain containing 3
RYR1 ryanodine receptor 1 (skeletal)
SDC4 syndecan 4
SIRT2 sirtuin 2
SKIL SKI-like proto-oncogene
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
SOSTDC1 sclerostin domain containing 1
SRXN1 sulfiredoxin 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TPMT thiopurine S-methyltransferase
TSLP thymic stromal lymphopoietin
UIMC1 ubiquitin interaction motif containing 1
UTRN utrophin
VASN vasorin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
YIPF6 Yip1 domain family, member 6
ZNF148 zinc finger protein 148