abnormality of the hypothalamus-pituitary axis Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Abnormality of the pituitary gland (also known as hypophysis), which is an endocrine gland that protrudes from the bottom of the hypothalamus at the base of the brain. The pituitary gland secretes the hormones ACTH, TSH, PRL, GH, endorphins, FSH, LH, oxytocin, and antidiuretic hormone. The secretion of hormones from the anterior pituitary is under the strict control of hypothalamic hormones, and the posterior pituitary is essentially an extension of the hypothalamus, so that hypothalamus and pituitary gland may be regarded as a functional unit. (Human Phenotype Ontology, HP_0000864)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0000864
Similar Terms
Downloads & Tools


24 genes associated with the abnormality of the hypothalamus-pituitary axis phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.75313
PDE8B phosphodiesterase 8B 1.42949
MPDU1 mannose-P-dolichol utilization defect 1 1.36759
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 1.36363
GYS1 glycogen synthase 1 (muscle) 0.522136
IL1R2 interleukin 1 receptor, type II 0.498792
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.474018
GLDN gliomedin 0.433116
ADGB androglobin 0.424122
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.413807
MAST4 microtubule associated serine/threonine kinase family member 4 0.411397
TMEM196 transmembrane protein 196 0.408206
ARMC9 armadillo repeat containing 9 0.40409
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.40409
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.40409
ZFPM1 zinc finger protein, FOG family member 1 0.403073
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.399622
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.398201
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.393942
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.387045
ARHGAP24 Rho GTPase activating protein 24 0.382662
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.376688
UPK1B uroplakin 1B 0.368093
AMPH amphiphysin 0.361805