ace Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description angiotensin I converting enzyme|This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 1636)
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Genes

103 genes co-occuring with the biological term ace in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ACAT1 acetyl-CoA acetyltransferase 1
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAM9 ADAM metallopeptidase domain 9
ADD1 adducin 1 (alpha)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AGTRAP angiotensin II receptor-associated protein
AMPD1 adenosine monophosphate deaminase 1
AMY2A amylase, alpha 2A (pancreatic)
APOC1 apolipoprotein C-I
APOE apolipoprotein E
BDKRB2 bradykinin receptor B2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CALCA calcitonin-related polypeptide alpha
CAT catalase
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CETP cholesteryl ester transfer protein, plasma
CILP2 cartilage intermediate layer protein 2
CKM creatine kinase, muscle
CMA1 chymase 1, mast cell
CRCP CGRP receptor component
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
ECE1 endothelin converting enzyme 1
EDN1 endothelin 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETV6 ets variant 6
F12 coagulation factor XII (Hageman factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
GH1 growth hormone 1
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPX1 glutathione peroxidase 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HP haptoglobin
ICAM1 intercellular adhesion molecule 1
IDE insulin-degrading enzyme
IL1B interleukin 1, beta
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
KNG1 kininogen 1
LEP leptin
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRTM3 leucine rich repeat transmembrane neuronal 3
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK8 mitogen-activated protein kinase 8
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MBL2 mannose-binding lectin (protein C) 2, soluble
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MSTN myostatin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
OTSC2 otosclerosis 2
OTSC5 otosclerosis 5
POMC proopiomelanocortin
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCB protein kinase C, beta
PRKCQ protein kinase C, theta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
RELN reelin
REN renin
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SOD2 superoxide dismutase 2, mitochondrial
TF transferrin
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound