acebutolol-1911 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the acebutolol-1911 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACAN aggrecan
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANAPC2 anaphase promoting complex subunit 2
APOM apolipoprotein M
ARFRP1 ADP-ribosylation factor related protein 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BGLAP bone gamma-carboxyglutamate (gla) protein
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C4ORF19 chromosome 4 open reading frame 19
CAPN5 calpain 5
CCDC85B coiled-coil domain containing 85B
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD47 CD47 molecule
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLDN15 claudin 15
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNPY3 canopy FGF signaling regulator 3
COASY CoA synthase
COL4A1 collagen, type IV, alpha 1
COL6A1 collagen, type VI, alpha 1
COPE coatomer protein complex, subunit epsilon
CYFIP2 cytoplasmic FMR1 interacting protein 2
DIO2 deiodinase, iodothyronine, type II
DNASE2 deoxyribonuclease II, lysosomal
FAM188A family with sequence similarity 188, member A
FASTK Fas-activated serine/threonine kinase
FLCN folliculin
FOSL2 FOS-like antigen 2
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPR3 G protein-coupled receptor 3
GRK6 G protein-coupled receptor kinase 6
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IL11 interleukin 11
IL13RA1 interleukin 13 receptor, alpha 1
KPTN kaptin (actin binding protein)
KRI1 KRI1 homolog (S. cerevisiae)
LIMK2 LIM domain kinase 2
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMF2 lipase maturation factor 2
MAGOHB mago-nashi homolog B (Drosophila)
MCOLN1 mucolipin 1
MED25 mediator complex subunit 25
METTL7A methyltransferase like 7A
MFSD11 major facilitator superfamily domain containing 11
MXD4 MAX dimerization protein 4
MYO9A myosin IXA
MYT1 myelin transcription factor 1
NAAA N-acylethanolamine acid amidase
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOTCH2 notch 2
NPAT nuclear protein, ataxia-telangiectasia locus
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
PAIP2B poly(A) binding protein interacting protein 2B
PCSK7 proprotein convertase subtilisin/kexin type 7
PHEX phosphate regulating endopeptidase homolog, X-linked
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPP5C protein phosphatase 5, catalytic subunit
PRRC2B proline-rich coiled-coil 2B
PSD3 pleckstrin and Sec7 domain containing 3
PSME4 proteasome (prosome, macropain) activator subunit 4
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RARG retinoic acid receptor, gamma
RECQL5 RecQ protein-like 5
RGS10 regulator of G-protein signaling 10
RHOBTB3 Rho-related BTB domain containing 3
SAMHD1 SAM domain and HD domain 1
SEC23A Sec23 homolog A (S. cerevisiae)
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SLC22A14 solute carrier family 22, member 14
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLK STE20-like kinase
SNX2 sorting nexin 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TCF4 transcription factor 4
TCP11L1 t-complex 11, testis-specific-like 1
TEX40 testis expressed 40
TK2 thymidine kinase 2, mitochondrial
TLN2 talin 2
TRD T cell receptor delta locus
TTC38 tetratricopeptide repeat domain 38
UBE2O ubiquitin-conjugating enzyme E2O
UBTF upstream binding transcription factor, RNA polymerase I
USF2 upstream transcription factor 2, c-fos interacting
WIZ widely interspaced zinc finger motifs
ZMAT5 zinc finger, matrin-type 5
ZNF124 zinc finger protein 124

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AIM1 absent in melanoma 1
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ATXN2 ataxin 2
AUH AU RNA binding protein/enoyl-CoA hydratase
BHLHE41 basic helix-loop-helix family, member e41
C12ORF29 chromosome 12 open reading frame 29
C21ORF91 chromosome 21 open reading frame 91
CBR4 carbonyl reductase 4
CCNA1 cyclin A1
CD302 CD302 molecule
CLK2 CDC-like kinase 2
CNTD2 cyclin N-terminal domain containing 2
CPOX coproporphyrinogen oxidase
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DMXL1 Dmx-like 1
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ERCC5 excision repair cross-complementation group 5
FAM102A family with sequence similarity 102, member A
FAM172A family with sequence similarity 172, member A
FDXR ferredoxin reductase
FMO4 flavin containing monooxygenase 4
GDI1 GDP dissociation inhibitor 1
GOLGA8B golgin A8 family, member B
GPATCH3 G patch domain containing 3
GTPBP8 GTP-binding protein 8 (putative)
H2AFY2 H2A histone family, member Y2
HACD2 3-hydroxyacyl-CoA dehydratase 2
HINFP histone H4 transcription factor
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
KCTD9 potassium channel tetramerization domain containing 9
KIAA1551 KIAA1551
KLHL2 kelch-like family member 2
KRT75 keratin 75, type II
KRT86 keratin 86, type II
MAD2L1BP MAD2L1 binding protein
MAVS mitochondrial antiviral signaling protein
MED23 mediator complex subunit 23
MFSD12 major facilitator superfamily domain containing 12
MT1HL1 metallothionein 1H-like 1
MXRA7 matrix-remodelling associated 7
MYNN myoneurin
NMD3 NMD3 ribosome export adaptor
NR1H2 nuclear receptor subfamily 1, group H, member 2
OARD1 O-acyl-ADP-ribose deacylase 1
OXR1 oxidation resistance 1
PDCD10 programmed cell death 10
PEX13 peroxisomal biogenesis factor 13
PIGK phosphatidylinositol glycan anchor biosynthesis, class K
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
POU2F1 POU class 2 homeobox 1
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPT1 palmitoyl-protein thioesterase 1
PRSS23 protease, serine, 23
PSAT1 phosphoserine aminotransferase 1
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB20 RAB20, member RAS oncogene family
RAD54L RAD54-like (S. cerevisiae)
RCOR3 REST corepressor 3
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNF122 ring finger protein 122
RNF220 ring finger protein 220
RPL23AP32 ribosomal protein L23a pseudogene 32
SALL2 spalt-like transcription factor 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH2B3 SH2B adaptor protein 3
SIPA1 signal-induced proliferation-associated 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SOAT1 sterol O-acyltransferase 1
TBC1D12 TBC1 domain family, member 12
TBX3 T-box 3
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TK1 thymidine kinase 1, soluble
TMEM183A transmembrane protein 183A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TPST2 tyrosylprotein sulfotransferase 2
TRAPPC12 trafficking protein particle complex 12
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TSLIG2 tRNA splicing ligase complex subunit 2
TSSC4 tumor suppressing subtransferable candidate 4
TTC26 tetratricopeptide repeat domain 26
TULP4 tubby like protein 4
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WASF3 WAS protein family, member 3
WDR13 WD repeat domain 13
ZNF562 zinc finger protein 562
ZSCAN5A zinc finger and SCAN domain containing 5A